Zarate A, Gelfand M C, Horton J D, Winchester J F, Gottlieb M J, Lazarus J M, Schreiner G E
Int J Artif Organs. 1980 Jan;3(1):15-7.
Pericardial effusion, diagnosed clinically or by echocardiography, was found in 13 of 16 regularly dialyzed patients (81%) receiving minoxidil for refractory hypertension. In a comparable group of 125 patients not receiving minoxidil, 28 patients (23%) had evidence of pericardial effusion, the difference between the groups being highly significant (p less than 0.0005). In minoxidil treated patients, the effusions resolved spontaneously in 4 (3 remaining on treatment), required pericardiocentesis (3), or pericardiectomy (1), and persisted in 4 (3 remaining on treatment). It is suggested that minoxidil treated dialysis patients be regulary examined for the development of potentially threatening pericardial effusions.
在16例接受米诺地尔治疗难治性高血压的规律透析患者中，有13例（81%）经临床诊断或超声心动图检查发现心包积液。在125例未接受米诺地尔治疗的对照患者中，有28例（23%）有心包积液的证据，两组之间的差异非常显著（p<0.0005）。在接受米诺地尔治疗的患者中，4例积液自发消退（3例继续治疗），3例需要心包穿刺，1例需要心包切除术，4例积液持续存在（3例继续治疗）。建议对接受米诺地尔治疗的透析患者定期检查，以发现可能危及生命的心包积液。
