Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
J Cardiovasc Med (Hagerstown). 2011 Mar;12(3):186-8. doi: 10.2459/jcm.0b013e328334fb07.
We present a case of drug-induced pericardial effusion in a patient with end-stage renal disease. Hypertension is frequent among patients with chronic renal failure and sometimes it is necessary to use agents, like minoxidil. Many papers have reported the association between minoxidil and pericardial effusion, both in dialysis patients and those with normal renal function. These effusions sometimes require drainage because of tamponade, but usually disappear after discontinuation of the drug, which is what happened in our patient. In any patient on dialysis treated with minoxidil, the appearance of pericardial effusion unresponsive to ultrafiltration should launch the suspicion of this complication and the drug should be withdrawn.
我们报告了一例终末期肾病患者的药物性心包积液。高血压在慢性肾衰竭患者中很常见，有时需要使用米诺地尔等药物。许多文献报道了米诺地尔与心包积液之间的关系，包括透析患者和肾功能正常的患者。这些积液有时会因为填塞而需要引流，但通常在停药后会消失，我们的患者就是如此。任何接受米诺地尔治疗的透析患者，如果出现心包积液且对超滤无反应，应怀疑发生这种并发症，应停用该药物。
