Pahl Paula M B, Horwitz Lawrence D
University of Colorado Health Sciences Center, Department of Medicine, Denver, CO 80262, USA.
Cancer Invest. 2005;23(8):683-91. doi: 10.1080/07357900500359976.
Iron is an essential micronutrient for the growth and function of all cells. It is, therefore, an attractive target for chemotherapeutic compounds. Numerous studies in vitro and in vivo provide evidence that iron chelators may be effective antitumor agents. Lipophilic iron chelators that are readily cell permeable and can bind intracellular iron stores may selectively kill cancer cells without damaging normal cells. In this review we discuss the role of iron in cellular processes and how these processes differ between normal and neoplastic cells. We also review the effects on normal and cancer cell growth of several lipophilic iron chelators.
铁是所有细胞生长和功能所必需的微量营养素。因此，它是化疗化合物的一个有吸引力的靶点。大量的体外和体内研究提供了证据，表明铁螯合剂可能是有效的抗肿瘤药物。亲脂性铁螯合剂易于透过细胞，能够结合细胞内的铁储存，可能会选择性地杀死癌细胞而不损害正常细胞。在这篇综述中，我们讨论了铁在细胞过程中的作用，以及这些过程在正常细胞和肿瘤细胞之间的差异。我们还综述了几种亲脂性铁螯合剂对正常细胞和癌细胞生长的影响。
