Zhang X, Beaulieu J-M, Gainetdinov R R, Caron M G
Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Box 3287, Durham, North Carolina 27710, USA.
Cell Mol Life Sci. 2006 Jan;63(1):6-11. doi: 10.1007/s00018-005-5417-4.
Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.
许多神经精神疾病被认为与大脑血清素能神经传递的失调有关。色氨酸羟化酶-2（TPH2）是控制大脑血清素合成的神经元特异性酶。越来越多的遗传学证据表明TPH2可能参与血清素相关的神经精神疾病；然而，TPH2的遗传变异程度，尤其是其可能的功能后果仍然未知。在这篇简短的综述中，我们将总结一些关于TPH2功能分析的最新发现。
