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来自地钱的双（联苄）类化合物抑制脂多糖诱导的RAW 264.7细胞中诱导型一氧化氮合酶：构效关系及分子机制研究

Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.

作者信息

Harinantenaina Liva, Quang Dang Ngoc, Takeshi Nishizawa, Hashimoto Toshihiro, Kohchi Chie, Soma Gen-Ichiro, Asakawa Yoshinori

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

出版信息

J Nat Prod. 2005 Dec;68(12):1779-81. doi: 10.1021/np0502589.

DOI:10.1021/np0502589
PMID:16378374
Abstract

The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.

摘要

评估了从地钱中分离出的19种双（联苄）化合物对RAW 264.7巨噬细胞中脂多糖诱导的一氧化氮合酶（NOS）的抑制作用。抑制一氧化氮（NO）生成需要酚羟基的存在以及7,8和/或7'/8'位的饱和结构。在所测试的化合物中，桑黄亭A的活性最强，其抑制活性与脂多糖诱导的诱导型一氧化氮合酶（iNOS）mRNA的抑制作用一致。

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