Subramaniam S, Abdullah A H R, Hairuzah I
Department of Otorhinolaryngology, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang.
Med J Malaysia. 2005 Aug;60(3):386-8.
Primary histoplasmosis of the larynx is not a common disease. Most cases of laryngeal histoplasmosis results from hematogenous spread of disseminated histoplasmosis usually originating from pulmonary infection by Histoplasma capsulatum. We report a 52-year-old male chronic smoker who had prolonged hoarseness and was initially diagnosed with laryngeal carcinoma. However, biopsy of the laryngeal mucosa confirmed the diagnosis of histoplasmosis. There were no signs of pulmonary or systemic involvement. Treatment with intravenous amphotericin B was given for a week and oral ketaconazole was given for a month with complete resolution of symptoms.
喉原发性组织胞浆菌病并不常见。大多数喉组织胞浆菌病病例是由播散性组织胞浆菌病经血行播散所致，通常源于荚膜组织胞浆菌引起的肺部感染。我们报告一例52岁男性慢性吸烟者，他长期声音嘶哑，最初被诊断为喉癌。然而，喉黏膜活检确诊为组织胞浆菌病。没有肺部或全身受累的迹象。给予静脉注射两性霉素B治疗一周，口服酮康唑治疗一个月，症状完全缓解。
