Ferrari Teresa C A, Soares João Marcos A, Salles José Maria P, Handam Júnia S, Azevedo Rosana C S, Xavier Marcelo A P, Faria Luciana C
Mycoses. 2009 Nov;52(6):539-40. doi: 10.1111/j.1439-0507.2008.01650.x. Epub 2009 Jan 9.
Histoplasma capsulatum infection involving the larynx is a rare manifestation, especially in immunocompetent individuals and a high index of suspicion is needed to establish the diagnosis correctly. We report a case of a 50-year-old Brazilian man who presented with progressive hoarseness and throat pain for 4 months. Laryngoscopy showed a supraglottic vegetant lesion, and the biopsies chronic granulomatous inflammation without any specific agent. A second laryngoscopy with biopsies was performed and after 17 days of incubation in specific medium, H. capsulatum was isolated. The patient was successfully treated with amphotericin B.
荚膜组织胞浆菌感染累及喉部是一种罕见的表现，尤其是在免疫功能正常的个体中，需要高度怀疑才能正确做出诊断。我们报告一例50岁巴西男性病例，该患者出现进行性声音嘶哑和咽痛4个月。喉镜检查显示声门上有赘生物性病变，活检显示慢性肉芽肿性炎症但未发现任何特异性病原体。进行了第二次喉镜检查及活检，在特定培养基中培养17天后，分离出荚膜组织胞浆菌。患者接受两性霉素B治疗后痊愈。
