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喉组织胞浆菌病:伪装的恶性肿瘤。

Laryngeal histoplasmosis: masquerading malignancy.

机构信息

ENT-HNS, Army Hospital Research and Referral, New Delhi, Delhi, India.

ENT-HNS, Army Hospital Research and Referral, New Delhi, Delhi, India

出版信息

BMJ Case Rep. 2022 Jul 11;15(7):e248738. doi: 10.1136/bcr-2022-248738.

DOI:10.1136/bcr-2022-248738
PMID:35817484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9274538/
Abstract

Laryngeal histoplasmosis is a very rare cause of laryngitis which is encountered usually in the immunosuppressed states but can also occur in immunologically intact status. We report a rare case of laryngeal histoplasmosis in a man in his 60s, a chronic smoker who presented with a history of progressive hoarseness for 3 months. The glottic growth was biopsied. The rarity of diagnosis was aided by histopathological examination of the tissue, which revealed histoplasmosis. Management was done with intravenous liposomal amphotericin B and oral itraconazole with complete resolution of symptoms.

摘要

喉组织胞浆菌病是一种非常罕见的喉炎病因,通常发生在免疫抑制状态下,但也可能发生在免疫正常状态下。我们报告了一例 60 多岁的男性喉组织胞浆菌病的罕见病例,他是一名慢性吸烟者,有 3 个月的进行性声音嘶哑病史。对声门上生长物进行了活检。组织学检查有助于诊断,结果显示为组织胞浆菌病。治疗采用静脉注射两性霉素 B 脂质体和口服伊曲康唑,症状完全缓解。

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Histoplasmosis of Larynx and Itraconazole as the Treatment of Choice.喉组织胞浆菌病及以伊曲康唑为首选治疗药物
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4899-4901. doi: 10.1007/s12070-021-02405-2. Epub 2021 Jan 31.
2
Histoplasma Capsulatum: Mechanisms for Pathogenesis.荚膜组织胞浆菌:发病机制的相关研究。
Curr Top Microbiol Immunol. 2019;422:157-191. doi: 10.1007/82_2018_114.
3
Histoplasmosis in non-endemic North-Western part of India.印度西北部非流行地区的组织胞浆菌病。
Indian J Med Microbiol. 2018 Jan-Mar;36(1):61-64. doi: 10.4103/ijmm.IJMM_18_12.
4
A Twenty-First-Century Perspective of Disseminated Histoplasmosis in India: Literature Review and Retrospective Analysis of Published and Unpublished Cases at a Tertiary Care Hospital in North India.印度播散性组织胞浆菌病的 21 世纪视角:印度北部一家三级护理医院发表和未发表病例的文献回顾和回顾性分析。
Mycopathologia. 2017 Dec;182(11-12):1077-1093. doi: 10.1007/s11046-017-0191-z. Epub 2017 Oct 27.
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Laboratory Diagnostics for Histoplasmosis.组织胞浆菌病的实验室诊断
J Clin Microbiol. 2017 Jun;55(6):1612-1620. doi: 10.1128/JCM.02430-16. Epub 2017 Mar 8.
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Laryngeal histoplasmosis.喉组织胞浆菌病
BMJ Case Rep. 2016 Aug 17;2016:bcr2016216423. doi: 10.1136/bcr-2016-216423.
7
An Intracellular Arrangement of Histoplasma capsulatum Yeast-Aggregates Generates Nuclear Damage to the Cultured Murine Alveolar Macrophages.荚膜组织胞浆菌酵母聚集体的细胞内排列对培养的小鼠肺泡巨噬细胞造成核损伤。
Front Microbiol. 2016 Jan 11;6:1526. doi: 10.3389/fmicb.2015.01526. eCollection 2015.
8
Histoplasmosis laryngeal: report first case in Colombia.喉组织胞浆菌病:哥伦比亚首例病例报告。
Colomb Med (Cali). 2014 Dec 30;45(4):186-9. eCollection 2014 Oct-Dec.
9
Subacute histoplasmosis with focal involvement of the epiglottis: importance of differential diagnosis.伴有会厌局灶性受累的亚急性组织胞浆菌病:鉴别诊断的重要性
Case Rep Otolaryngol. 2014;2014:235975. doi: 10.1155/2014/235975. Epub 2014 Feb 5.
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