人巨细胞病毒UL131A、UL130和UL128基因在野外分离株中高度保守。

Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates.

作者信息

Baldanti F, Paolucci S, Campanini G, Sarasini A, Percivalle E, Revello M G, Gerna G

机构信息

Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy.

出版信息

Arch Virol. 2006 Jun;151(6):1225-33. doi: 10.1007/s00705-005-0696-5. Epub 2005 Dec 29.

DOI:10.1007/s00705-005-0696-5

PMID:16380811

Abstract

Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.

摘要

人巨细胞病毒（HCMV）的UL131A、UL130和UL128基因的编码序列在34株来自原发性HCMV感染孕妇及其胎儿或新生儿、实体器官移植受者和艾滋病患者的临床分离株中高度保守。未观察到菌株聚类现象。相比之下，UL55（gB编码基因）测序可将34株分离株分为4种基因型。UL131A - UL128基因座的保守性与以下结论一致：这三种编码蛋白对于HCMV在内皮细胞中的生长以及病毒向白细胞的转移均至关重要。