肾移植受者的皮肤癌与HLA频率

Skin cancers and HLA frequencies in renal transplant recipients.

作者信息

Czarnecki D, Watkins F, Leahy S, Dyall-Smith D, Levis A, Nicholson I, Tait B

机构信息

Repatriation General Hospital, Heidelberg, Australia.

出版信息

Dermatology. 1992;185(1):9-11. doi: 10.1159/000247394.

DOI:10.1159/000247394

PMID:1638083

Abstract

An association between HLA DR7 and the development of multiple non-melanoma skin cancer was detected in immunosuppressed patients in southern Australia. The relative risk was 2.6 which was lower than for immunocompetent patients with the same skin cancers. HLA frequencies of renal transplant recipients with multiple skin cancers were determined. The types HLA B27 and HLA Dr7 were found in significantly higher frequency, and there was no absence of HLA A11.

摘要

在澳大利亚南部的免疫抑制患者中，检测到HLA DR7与多种非黑色素瘤皮肤癌的发生之间存在关联。相对风险为2.6，低于患有相同皮肤癌的免疫功能正常患者。测定了患有多种皮肤癌的肾移植受者的HLA频率。发现HLA B27和HLA Dr7类型的频率显著更高，且不存在HLA A11缺失的情况。