Glover M T, Bodmer J, Bodmer W, Kennedy L J, Brown J, Navarrete C, Kwan J T, Leigh I M
Department of Dermatology, Royal London Hospital, U.K.
Eur J Cancer. 1993;29A(4):520-4. doi: 10.1016/s0959-8049(05)80143-1.
An increased frequency of human leukocyte antigen (HLA)-DR1 was found in 49 non-immunosuppressed patients with non-melanoma skin cancer (NMSC), being highest in patients under the age of 60 with multiple squamous cell carcinomas (SCC). Of 266 patients receiving long-term immunosuppression following renal transplantation 46 (17%) were found to have NMSC. No increase in HLA-DR1 was found in renal transplant recipients (RTR) with non-melanoma skin cancer (RTR+C) when compared with matched renal transplant recipients without skin cancer (matched RTR-C), or when compared with healthy controls. There was an increased frequency of DQw2 in RTR+C, most pronounced in RTR with SCC (61.9% compared with 18.75% in matched RTR-C), giving a relative risk of 13.98. We found statistically significant differences in the frequency of a number of HLA antigens on comparing RTR+C with healthy controls, but none of these differences were found when we compared RTR+C against matched RTR-C.
在49例非免疫抑制的非黑色素瘤皮肤癌（NMSC）患者中发现人类白细胞抗原（HLA）-DR1频率增加，在60岁以下患有多发性鳞状细胞癌（SCC）的患者中最高。在266例肾移植后接受长期免疫抑制的患者中，有46例（17%）被发现患有NMSC。与匹配的无皮肤癌的肾移植受者（匹配的RTR-C）相比，或与健康对照相比，患有非黑色素瘤皮肤癌的肾移植受者（RTR+C）中未发现HLA-DR1增加。RTR+C中DQw2频率增加，在患有SCC的RTR中最为明显（61.9%，而匹配的RTR-C中为18.75%），相对风险为13.98。在将RTR+C与健康对照进行比较时，我们发现多种HLA抗原的频率存在统计学显著差异，但在将RTR+C与匹配的RTR-C进行比较时未发现这些差异。
