人类白细胞抗原与多发性皮肤癌

HLA and multiple skin carcinomas.

作者信息

Cerimele D, Contu L, Carcassi C, Costa G, La Nasa G, Sanna E, Campus G V

机构信息

Institute of Dermatology, University of Sassari, Italy.

出版信息

Dermatologica. 1988;176(4):176-81. doi: 10.1159/000248700.

DOI:10.1159/000248700

PMID:3378654

Abstract

The presence of HLA-associated genetic factors in patients with multiple skin carcinomas was investigated. 43 patients affected by multiple basal and squamous cell carcinomas and 220 healthy age-matched controls were typed for 72 HLA-A, B, C, DR antigens. A negative association of B-17 (mostly B-58) and a positive association of Cw-3 and DR-1 was observed in patients with multiple basal cell carcinomas; a similar negative association with B-58 and positive association with DR-1 was seen in patients with squamous cell carcinomas. The results of this study suggest the presence of resistance factors to the development of skin cancers associated with B-17 (B-58) antigen.

摘要

对多发性皮肤癌患者中HLA相关遗传因素的存在情况进行了研究。对43例患有多发性基底细胞癌和鳞状细胞癌的患者以及220名年龄匹配的健康对照者进行了72种HLA - A、B、C、DR抗原分型。在多发性基底细胞癌患者中观察到B - 17（主要是B - 58）呈负相关，Cw - 3和DR - 1呈正相关；在鳞状细胞癌患者中也观察到与B - 58的类似负相关以及与DR - 1的正相关。本研究结果表明存在与B - 17（B - 58）抗原相关的皮肤癌发生抗性因素。