体外扩增过程中造血干细胞的增殖性衰老
Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.
作者信息
Piacibello Wanda, Gammaitoni Loretta, Pignochino Ymera
机构信息
Laboratory of Medical Oncology, Department of Oncological Sciences, IRCC Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Turin, Italy.
出版信息
Folia Histochem Cytobiol. 2005;43(4):197-202.
The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
造血干细胞（HSC）移植的良好结果受到低剂量CD34+细胞输注的阻碍。移植的造血干细胞会经历复制应激，由于端粒迅速缩短，导致加速衰老。与成人造血干细胞相比，就端粒长度和端粒酶活性而言，人脐带血造血干细胞的扩增有助于获得大量“高质量”细胞。
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