Cunha B A
Infectious Disease Division, Winthrop-University Hospital, Mineola, New York.
Clin Ther. 1992 May-Jun;14(3):418-25.
The development of beta-lactamase-producing strains of the common respiratory tract pathogens Hemophilus influenzae and Moraxella catarrhalis has caused increasing resistance to a number of antimicrobial agents, including ampicillin and amoxicillin, that are traditionally used to treat respiratory tract infections. Because antimicrobial therapy for upper and lower respiratory tract infections is usually empiric, an understanding of beta-lactamase-mediated resistance and its implications for antibiotic therapy is critical for the successful treatment of these infections.
常见呼吸道病原体流感嗜血杆菌和卡他莫拉菌产β-内酰胺酶菌株的出现，已导致对包括氨苄西林和阿莫西林在内的多种传统用于治疗呼吸道感染的抗菌药物产生了越来越高的耐药性。由于上、下呼吸道感染的抗菌治疗通常是经验性的，了解β-内酰胺酶介导的耐药性及其对抗生素治疗的影响对于成功治疗这些感染至关重要。
