风疹病毒与富克斯异色性虹膜睫状体炎有关。
Rubella virus is associated with fuchs heterochromic iridocyclitis.
作者信息
de Groot-Mijnes Jolanda D F, de Visser Lenneke, Rothova Aniki, Schuller Margje, van Loon Anton M, Weersink Annemarie J L
机构信息
Department of Virology, Eijkman-Winkler Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
出版信息
Am J Ophthalmol. 2006 Jan;141(1):212-214. doi: 10.1016/j.ajo.2005.07.078.
PURPOSE
To determine whether rubella virus (RV) is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).
DESIGN
Retrospective patient-controlled study.
METHODS
Intraocular immunoglobulin G production against RV, herpes simplex virus (HSV), varicella zoster virus (VZV), and Toxoplasma gondii was determined in the aqueous humor of 14 patients with FHI, 13 control subjects with herpetic uveitis anterior, and 19 control subjects with ocular toxoplasmosis by calculation of the Goldmann-Witmer coefficient (GWC).
RESULTS
All patients and control subjects were seropositive for RV. Intraocular antibody production (GWC >3) against RV was found in 13 of 14 patients (93%) with FHI. Intraocular antibody production against HSV, VZV, or T gondii was not detected. None of the control subjects with herpetic uveitis anterior or with toxoplasma chorioretinitis had a positive GWC for rubella virus (P < .0001, Fisher exact test).
CONCLUSION
Rubella virus, but not HSV, VZV, or T gondii, is associated with FHI.
目的
确定风疹病毒（RV）是否参与了富克斯异色性虹膜睫状体炎（FHI）的发病机制。
设计
回顾性患者对照研究。
方法
通过计算戈德曼 - 维特默系数（GWC），测定了14例FHI患者、13例疱疹性前葡萄膜炎对照受试者和19例眼弓形虫病对照受试者房水中针对RV、单纯疱疹病毒（HSV）、水痘 - 带状疱疹病毒（VZV）和弓形虫的眼内免疫球蛋白G产生情况。
结果
所有患者和对照受试者RV血清学均为阳性。14例FHI患者中有13例（93%）检测到针对RV的眼内抗体产生（GWC>3）。未检测到针对HSV、VZV或弓形虫的眼内抗体产生。疱疹性前葡萄膜炎或弓形虫脉络膜视网膜炎的对照受试者中，无一例风疹病毒GWC呈阳性（P<.0001，Fisher精确检验）。
结论
与FHI相关的是风疹病毒，而非HSV、VZV或弓形虫。
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