风疹病毒可能是 Fuchs 异色性虹膜睫状体炎的病因之一。
Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis.
机构信息
Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1487-91. doi: 10.1007/s00417-010-1434-6. Epub 2010 Jun 29.
BACKGROUND
To determine whether rubella virus is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).
METHODS
Fourteen patients (14 eyes) diagnosed with FHI based on characteristic ocular manifestations and eight control subjects were studied. Aqueous humor (AH) samples from 14 FHI patients and one vitreous sample from a FHI patient were analyzed for intraocular antibody production against rubella virus by calculation of the Goldmann-Witmer coefficient (GWC). Viral detection by nested polymerase chain reaction and isolation by culture in RK-13 cells were conducted in nine FHI patients. In addition to laboratory examinations, medical history of rubella virus vaccination was also obtained.
RESULTS
Ten patients with FHI examined showed intraocular synthesis of rubella virus antibodies (GWC > 3). A high index of rubella virus antibody production was also found in the vitreous sample (GWC = 30.6). GWC in all control subjects were below detectable level. The rubella genome was detected in two of nine patients, and rubella virus was isolated from one of nine patients with FHI. None of the patients with FHI had been vaccinated against rubella.
CONCLUSIONS
Our laboratory data strongly suggest a relationship between FHI and rubella virus.
背景
为了确定风疹病毒是否参与了 Fuchs 异色性虹膜睫状体炎（FHI）的发病机制。
方法
根据特征性眼部表现，对 14 例 FHI 患者（14 只眼）和 8 名对照者进行了研究。通过计算 Goldmann-Witmer 系数（GWC），分析了 14 例 FHI 患者的房水（AH）样本和 1 例 FHI 患者的玻璃体样本中针对风疹病毒的眼内抗体产生情况。对 9 例 FHI 患者进行了巢式聚合酶链反应检测和 RK-13 细胞培养分离病毒。除了实验室检查外，还获得了风疹病毒疫苗接种的病史。
结果
10 例接受检查的 FHI 患者表现出风疹病毒抗体的眼内合成（GWC>3）。在玻璃体样本中也发现了高指数的风疹病毒抗体产生（GWC=30.6）。所有对照者的 GWC 均低于检测水平。在 9 例患者中的 2 例中检测到风疹病毒基因组，在 9 例 FHI 患者中的 1 例中分离到风疹病毒。FHI 患者均未接种风疹疫苗。
结论
我们的实验室数据强烈提示 FHI 与风疹病毒之间存在关系。
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