Zhang Zhouning, Abrahams Melissa-Rose, Hunt Lawrence A, Suttles Jill, Marshall William, Lahiri Debomoy K, Kotwal Girish J
Department of Microbiology and Immunology, University of Louisville School of Medicine, Kentucky 40202, USA.
Ann N Y Acad Sci. 2005 Nov;1056:69-86. doi: 10.1196/annals.1352.005.
The vaccinia virus N1L ORF encodes a protein that enhances virulence and replication of the virus by an unknown mechanism. It has been studied for its ability to enhance viral replication and dissemination in the brain and more recently has been linked to an immunomodulatory role in which it inhibits the activation of cytokine transcription activators in Toll-like receptor signaling pathways after pathogen recognition. The effect of N1L on the release of cytokines from human primary monocytes was investigated. Secretion of the proinflammatory, antiviral cytokines TNF-alpha, IL-1beta, IFN-alpha, IFN-beta, and the anti-inflammatory cytokine IL-10 was found to be inhibited by the presence of the N1L protein.
痘苗病毒N1L开放阅读框编码一种蛋白质，该蛋白质通过未知机制增强病毒的毒力和复制。人们对其增强病毒在脑内复制和传播的能力进行了研究，最近还发现它具有免疫调节作用，即在病原体识别后，它能抑制Toll样受体信号通路中细胞因子转录激活剂的激活。研究了N1L对人原代单核细胞释放细胞因子的影响。发现N1L蛋白的存在会抑制促炎、抗病毒细胞因子肿瘤坏死因子-α、白细胞介素-1β、干扰素-α、干扰素-β以及抗炎细胞因子白细胞介素-10的分泌。
