Kulkarni Amod P, Ghebremariam Yohannes T, Kotwal Girish J
Division of Medical Virology, IIDMM, Faculty of Health Sciences, Medical School, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Ann N Y Acad Sci. 2005 Nov;1056:100-12. doi: 10.1196/annals.1352.007.
Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and QurNa, respectively) and the vaccinia virus complement control protein (VCP). The comparative study indicated that CurNa inhibited the classical complement pathway dose dependently (IC50 = 404 microM). CurNa was more active than RANa, but less active than QurNa. VCP was about 2,212, 2,786, and 4,520 times more active than QurNa, CurNa, and RANa, respectively. Further study revealed that CurNa dose dependently inhibited zymosan-induced activation of the alternate pathway of complement activation.
姜黄素（Cur）是姜黄中的金黄色酚类化合物，其药用特性已得到充分研究。在当前的研究中，测试了用氢氧化钠溶液溶解的姜黄素（CurNa）的体外补体抑制活性，并将其与用氢氧化钠溶解的迷迭香酸（RA）和槲皮素（Qur）（分别为RANa和QurNa）以及痘苗病毒补体控制蛋白（VCP）进行比较。比较研究表明，CurNa剂量依赖性地抑制经典补体途径（IC50 = 404 microM）。CurNa比RANa更具活性，但比QurNa活性低。VCP的活性分别比QurNa、CurNa和RANa高约2212倍、2786倍和4520倍。进一步的研究表明，CurNa剂量依赖性地抑制酵母聚糖诱导的补体激活替代途径的激活。
