转运RNA中的动态转变是由溶剂诱导的。
Dynamic transition in tRNA is solvent induced.
作者信息
Caliskan Gokhan, Briber Robert M, Thirumalai D, Garcia-Sakai Victoria, Woodson Sarah A, Sokolov Alexei P
机构信息
Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218-2685, USA.
出版信息
J Am Chem Soc. 2006 Jan 11;128(1):32-3. doi: 10.1021/ja056444i.
Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.
利用中子散射光谱研究了转运核糖核酸（tRNA）的动力学。尽管蛋白质和核糖核酸（RNA）在结构和主链结构上存在巨大差异，但水合tRNA与水合溶菌酶在相同温度下发生动态转变。RNA和蛋白质动态转变的相似性支持了这是由溶剂诱导的观点。由于tRNA基本上没有甲基基团，结果还表明甲基基团不是生物大分子动态转变的主要贡献者。然而，它们可能解释了在低温下观察到的tRNA和溶菌酶动力学的强烈差异。
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