Low L-F, Anstey K J, Jorm A F, Rodgers B, Christensen H
Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia.
Climacteric. 2005 Dec;8(4):380-9. doi: 10.1080/13697130500345240.
Greater lifetime estrogen exposure has been postulated to result in better cognition in later life, particularly in the area of verbal memory. In women, the highest levels of endogenous estrogen occur during their reproductive period, between menarche and menopause.
To investigate the association between reproductive period and cognition.
The sample consisted of 760 naturally postmenopausal women aged 60-64 years (mean age 62.5 +/- 1.5 years) participating in the PATH Through Life Study who were randomly drawn from the population of Canberra, Australia. Participants were administered a verbal learning test (immediate recall and 1-minute delay), the Mini-Mental State Examination (MMSE), digit span backwards, the Symbol-Digit Modalities Test and simple and choice reaction time tests.
There were no significant associations detected between reproductive period and performance on any of the cognitive tests, either before or after controlling for potential confounding variables.
Reproductive period, a surrogate measure of endogenous estrogen exposure, had no detectable effect on cognitive performance in this sample.
据推测，一生中较高的雌激素暴露水平会使晚年认知能力更好，尤其是在言语记忆方面。在女性中，内源性雌激素水平最高的时期是在她们的生殖期，即初潮至绝经之间。
研究生殖期与认知之间的关联。
样本包括760名年龄在60 - 64岁（平均年龄62.5±1.5岁）的自然绝经后女性，她们参与了“贯穿一生之路”研究，是从澳大利亚堪培拉的人群中随机抽取的。参与者接受了言语学习测试（即时回忆和延迟1分钟回忆）、简易精神状态检查表（MMSE）、倒背数字、符号数字模式测试以及简单和选择反应时间测试。
在控制潜在混杂变量之前或之后，生殖期与任何认知测试的表现之间均未发现显著关联。
生殖期作为内源性雌激素暴露的替代指标，在该样本中对认知表现没有可检测到的影响。
