霍奇金淋巴瘤患者及其亲属的爱泼斯坦-巴尔病毒载量与抗病毒衣壳免疫球蛋白G滴度之间的正相关。
Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives.
作者信息
Besson Caroline, Amiel Corinne, Le-Pendeven Catherine, Brice Pauline, Fermé Christophe, Carde Patrice, Hermine Olivier, Raphael Martine, Abel Laurent, Nicolas Jean-Claude
机构信息
Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté Necker, Université de Paris René Descartes INSERM U550, France.
出版信息
J Clin Microbiol. 2006 Jan;44(1):47-50. doi: 10.1128/JCM.44.1.47-50.2006.
Abstract
Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.
摘要
爱泼斯坦-巴尔病毒（EBV）感染的标志物包括外周血单个核细胞中特定血清学滴度和病毒载量（VLo）的检测指标。很少有研究调查这两种表型之间的相关性。在此，我们发现病毒载量与抗EBV核抗原1型或抗早期抗原免疫球蛋白G（IgG）滴度之间均无相关性，但在霍奇金淋巴瘤患者的外周血单个核细胞中，抗病毒衣壳抗原（VCA）IgG滴度随病毒载量升高而增加（P = 3.10⁻³）。在患者的健康一级亲属（父母和兄弟姐妹）中也观察到类似模式（P = 6.10⁻⁴）。我们的结果表明，抗VCA IgG滴度和EBV病毒载量是EBV的特定相关表型。
相似文献
1
Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives.霍奇金淋巴瘤患者及其亲属的爱泼斯坦-巴尔病毒载量与抗病毒衣壳免疫球蛋白G滴度之间的正相关。
J Clin Microbiol. 2006 Jan;44(1):47-50. doi: 10.1128/JCM.44.1.47-50.2006.
2
Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas.来自与爱泼斯坦-巴尔病毒相关淋巴瘤家族的一级亲属中抗病毒衣壳抗原抗体水平的强相关性。
J Infect Dis. 2009 Apr 15;199(8):1121-7. doi: 10.1086/597424.
3
4
[Elevated Epstein-Barr virus antibodies in patients with Hodgkin's disease].[霍奇金病患者中升高的爱泼斯坦-巴尔病毒抗体]
Srp Arh Celok Lek. 1998 Mar-Apr;126(3-4):97-100.
5
Comparison of plasma Epstein-Barr virus (EBV) DNA levels and serum EBV immunoglobulin A/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma.鼻咽癌患者血浆中爱泼斯坦-巴尔病毒（EBV）DNA水平与血清EBV免疫球蛋白A/病毒衣壳抗原抗体滴度的比较。
Cancer. 2004 Mar 15;100(6):1162-70. doi: 10.1002/cncr.20099.
6
7
[Simultaneous detection of IgM antibodies against the hepatitis A virus and the viral capsid antigen of Epstein-Barr virus in acute hepatitis].[急性肝炎中甲型肝炎病毒IgM抗体与EB病毒病毒衣壳抗原的同时检测]
Gastroenterol Clin Biol. 1985 Feb;9(2):109-12.
8
Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis.霍奇金病与爱泼斯坦-巴尔病毒。诊断前抗体模式的改变。
N Engl J Med. 1989 Mar 16;320(11):689-95. doi: 10.1056/NEJM198903163201103.
9
10
Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus.肾移植受者淋巴增生性疾病的临床谱及爱泼斯坦-巴尔病毒作用的证据
Cancer Res. 1981 Nov;41(11 Pt 1):4253-61.
引用本文的文献
1
In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis.对多发性硬化症患者血清中针对爱泼斯坦-巴尔病毒生命周期蛋白、EBNA1、ANO2、胶质细胞粘附分子和CRYAB肽的抗体进行深入分析。
Front Immunol. 2024 Dec 17;15:1487523. doi: 10.3389/fimmu.2024.1487523. eCollection 2024.
2
Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma.人类白细胞抗原-DQA1*04:01 和 rs2040406 变异与儿童伯基特淋巴瘤风险升高相关。
Commun Biol. 2024 Jan 5;7(1):41. doi: 10.1038/s42003-023-05701-5.
3
Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage.针对裂解、潜伏和可能交叉反应的 EBV 抗原的血清反应平均在 MS 引起临床前神经轴突损伤前 10 年出现。
J Neurol Neurosurg Psychiatry. 2024 Mar 13;95(4):325-332. doi: 10.1136/jnnp-2023-331868.
4
Uncovering the Role of Epstein-Barr Virus Infection Markers for Remission in Rheumatoid Arthritis.揭示爱泼斯坦-巴尔病毒感染标志物在类风湿关节炎缓解中的作用。
Biomedicines. 2023 Aug 24;11(9):2375. doi: 10.3390/biomedicines11092375.
5
Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot.非洲人群中针对爱泼斯坦-巴尔病毒抗体反应的全基因组关联研究：一项试点研究。
Glob Health Epidemiol Genom. 2017 Nov 27;2:e18. doi: 10.1017/gheg.2017.16. eCollection 2017.
6
Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology.针对常见病毒的抗体水平低与抗瓜氨酸化蛋白抗体阳性的类风湿关节炎相关；对疾病发病机制的影响。
Arthritis Res Ther. 2017 Sep 30;19(1):219. doi: 10.1186/s13075-017-1423-9.
7
Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.多发性硬化症中爱泼斯坦-巴尔病毒感染的T细胞控制缺陷
Clin Transl Immunology. 2017 Jan 20;6(1):e126. doi: 10.1038/cti.2016.87. eCollection 2017 Jan.
8
Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy.血清或血浆中的抗JC病毒抗体水平进一步明确了那他珠单抗相关进展性多灶性白质脑病的风险。
Ann Neurol. 2014 Dec;76(6):802-12. doi: 10.1002/ana.24286. Epub 2014 Oct 24.
9
Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.连锁与关联研究相结合表明，人类白细胞抗原II类变体控制着针对爱泼斯坦-巴尔病毒抗原的抗体水平。
PLoS One. 2014 Jul 15;9(7):e102501. doi: 10.1371/journal.pone.0102501. eCollection 2014.
10
Childhood environments and cytomegalovirus serostatus and reactivation in adults.儿童期环境与成人巨细胞病毒血清学状态及再激活
Brain Behav Immun. 2014 Aug;40:174-81. doi: 10.1016/j.bbi.2014.03.010. Epub 2014 Mar 25.
本文引用的文献
1
Phenotype and frequency of Epstein-Barr virus-infected cells in pretreatment blood samples from patients with Hodgkin lymphoma.霍奇金淋巴瘤患者预处理血液样本中爱泼斯坦-巴尔病毒感染细胞的表型和频率。
Br J Haematol. 2005 May;129(4):511-9. doi: 10.1111/j.1365-2141.2005.05483.x.
2
Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo.终末分化为浆细胞启动了爱泼斯坦-巴尔病毒在体内的复制周期。
J Virol. 2005 Jan;79(2):1296-307. doi: 10.1128/JVI.79.2.1296-1307.2005.
3
Epstein-Barr viral load as a marker of lymphoma in AIDS patients.爱泼斯坦-巴尔病毒载量作为艾滋病患者淋巴瘤的标志物
J Med Virol. 2005 Jan;75(1):59-69. doi: 10.1002/jmv.20238.
4
Epstein-Barr virus: 40 years on.爱泼斯坦-巴尔病毒：40年过去了。
Nat Rev Cancer. 2004 Oct;4(10):757-68. doi: 10.1038/nrc1452.
5
Molecular parameters for precise diagnosis of asymptomatic Epstein-Barr virus reactivation in healthy carriers.用于精确诊断健康携带者中无症状EB病毒再激活的分子参数。
J Clin Microbiol. 2003 Dec;41(12):5419-28. doi: 10.1128/JCM.41.12.5419-5428.2003.
6
High Epstein-Barr virus (EBV) DNA loads in HIV-infected patients: correlation with antiretroviral therapy and quantitative EBV serology.人类免疫缺陷病毒（HIV）感染患者中高EB病毒（EBV）DNA载量：与抗逆转录病毒治疗及EBV定量血清学的相关性
AIDS. 2002 May 3;16(7):993-1001. doi: 10.1097/00002030-200205030-00005.
7
Routine use of real-time quantitative PCR for laboratory diagnosis of Epstein-Barr virus infections.实时定量聚合酶链反应在爱泼斯坦-巴尔病毒感染实验室诊断中的常规应用。
J Med Virol. 2002 Mar;66(3):360-9. doi: 10.1002/jmv.2153.
8
9
Detection of Epstein-Barr virus (EBV) genomes in the serum of patients with EBV-associated Hodgkin's disease.在与爱泼斯坦-巴尔病毒（EBV）相关的霍奇金淋巴瘤患者血清中检测EBV基因组。
Int J Cancer. 1999 Aug 20;84(4):442-8. doi: 10.1002/(sici)1097-0215(19990820)84:4<442::aid-ijc20>3.0.co;2-j.
10
High Epstein-Barr virus serum load and elevated titers of anti-ZEBRA antibodies in patients with EBV-harboring tumor cells of Hodgkin's disease.霍奇金淋巴瘤中携带EB病毒肿瘤细胞的患者，血清中爱泼斯坦-巴尔病毒载量高，抗ZEBRA抗体滴度升高。
J Med Virol. 1999 Apr;57(4):383-9. doi: 10.1002/(sici)1096-9071(199904)57:4<383::aid-jmv10>3.0.co;2-3.
Zotero 插件