Young Lawrence S, Rickinson Alan B
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK.
Nat Rev Cancer. 2004 Oct;4(10):757-68. doi: 10.1038/nrc1452.
Epstein-Barr virus (EBV) was discovered 40 years ago from examining electron micrographs of cells cultured from Burkitt's lymphoma, a childhood tumour that is common in sub-Saharan Africa, where its unusual geographical distribution - which matches that of holoendemic malaria -indicated a viral aetiology. However, far from showing a restricted distribution, EBV - a gamma-herpesvirus - was found to be widespread in all human populations and to persist in the vast majority of individuals as a lifelong, asymptomatic infection of the B-lymphocyte pool. Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours.
爱泼斯坦-巴尔病毒（EBV）于40年前从对培养自伯基特淋巴瘤细胞的电子显微镜照片检查中被发现，伯基特淋巴瘤是一种儿童肿瘤，在撒哈拉以南非洲地区很常见，其异常的地理分布——与疟疾高度流行地区一致——表明存在病毒病因。然而，与所显示的有限分布情况大相径庭的是，EBV——一种γ疱疹病毒——被发现广泛存在于所有人群中，并且在绝大多数个体中作为B淋巴细胞库的终身无症状感染而持续存在。尽管EBV如此普遍，但EBV与“地方性”伯基特淋巴瘤之间的联系被证明是一致的，并且成为了在这种病毒与肿瘤之间发现的一系列出乎意料的广泛关联中的第一个。
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