Besson Caroline, Amiel Corinne, Le-Pendeven Catherine, Plancoulaine Sabine, Bonnardel Colette, Ranque Brigitte, Abbed Karim, Brice Pauline, Fermé Christophe, Carde Patrice, Hermine Olivier, Raphael Martine, Bresson Jean-Louis, Nicolas Jean-Claude, Gessain Antoine, Dethe Guy, Abel Laurent
Laboratoire de Génétique Humaine des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, Unité 550, France.
J Infect Dis. 2009 Apr 15;199(8):1121-7. doi: 10.1086/597424.
Markers of Epstein-Barr virus (EBV) infection include anti-viral capsid antigen (VCA) immunoglobulin (Ig) G. High anti-VCA titers are associated with EBV-related lymphoproliferation, such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL).
Intrafamilial correlations of anti-VCA IgG levels were studied in 3 settings: 127 families recruited through patients with HL in France (population A), 31 families recruited through patients with BL in Uganda (population B), and 74 large families from a general population in Cameroon (population C). Titers were determined by enzyme-linked immunosorbent assay (populations A and C) or by immunofluorescence analysis (population B).
In populations A and B, the anti-VCA IgG titers of the relatives of patients with HL or BL increased significantly (P = .01 and P < .001, respectively) with those of the index case patient. In all 3 populations, anti-VCA IgG titers were significantly correlated (P < .001 for A, P = .002 for B, and P < .001 for C) between genetically related individuals (father-offspring, mother-offspring, and sibling-sibling) but not between spouses. Similar results were obtained for population A after adjustment for total IgG levels. In all cases, the pattern of correlations was consistent with a polygenic model, with heritability ranging from 0.32 to 0.48.
These results provide evidence for the genetic control of anti-VCA IgG titers and pave the way for identification of the loci involved.
爱泼斯坦-巴尔病毒（EBV）感染的标志物包括抗病毒衣壳抗原（VCA）免疫球蛋白（Ig）G。高抗VCA滴度与EBV相关的淋巴增殖性疾病有关，如伯基特淋巴瘤（BL）和霍奇金淋巴瘤（HL）。
在3种情况下研究了抗VCA IgG水平的家族内相关性：通过法国HL患者招募的127个家庭（A人群）、通过乌干达BL患者招募的31个家庭（B人群）以及喀麦隆普通人群中的74个大家庭（C人群）。通过酶联免疫吸附测定法（A和C人群）或免疫荧光分析（B人群）测定滴度。
在A和B人群中，HL或BL患者亲属的抗VCA IgG滴度随索引病例患者的滴度显著增加（分别为P = 0.01和P < 0.001）。在所有3个人群中，遗传相关个体（父子、母子和兄弟姐妹）之间的抗VCA IgG滴度显著相关（A人群P < 0.001，B人群P = 0.002，C人群P < 0.001），但配偶之间不相关。对A人群进行总IgG水平调整后获得了类似结果。在所有情况下，相关性模式与多基因模型一致，遗传度范围为0.32至0.48。
这些结果为抗VCA IgG滴度的遗传控制提供了证据，并为确定相关基因座铺平了道路。
