耐甲氧西林凝固酶阴性葡萄球菌和甲氧西林敏感金黄色葡萄球菌菌株的鼻腔共同定植是否频繁发生，足以构成通过分子方法测定耐甲氧西林金黄色葡萄球菌出现假阳性结果的风险？
Does nasal cocolonization by methicillin-resistant coagulase-negative staphylococci and methicillin-susceptible Staphylococcus aureus strains occur frequently enough to represent a risk of false-positive methicillin-resistant S. aureus determinations by molecular methods?
作者信息
Becker Karsten, Pagnier Isabelle, Schuhen Brigitte, Wenzelburger Frauke, Friedrich Alexander W, Kipp Frank, Peters Georg, von Eiff Christof
机构信息
University of Münster, Institute of Medical Microbiology, D-48149 Münster.
出版信息
J Clin Microbiol. 2006 Jan;44(1):229-31. doi: 10.1128/JCM.44.1.229-231.2006.
Abstract
By analyzing the colonization of the anterior nares in cardiothoracic surgery patients on admission, nasal cocolonization by methicillin-susceptible Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci was detected in 8/235 (3.4%) specimens. Consequently, in a low-methicillin-resistant S. aureus (MRSA) setting, a molecular MRSA screening test targeting the mecA gene and an S. aureus-specific gene in parallel and applied directly to clinical specimens would be associated with an unacceptable positive predictive value of about 40%.
摘要
通过分析心胸外科手术患者入院时前鼻孔的定植情况，在235份标本中的8份（3.4%）检测到甲氧西林敏感金黄色葡萄球菌和耐甲氧西林凝固酶阴性葡萄球菌的鼻腔共同定植。因此，在耐甲氧西林金黄色葡萄球菌（MRSA）发生率较低的情况下，一种同时针对mecA基因和金黄色葡萄球菌特异性基因并直接应用于临床标本的分子MRSA筛查试验，其阳性预测值约为40%，这是不可接受的。
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Does nasal cocolonization by methicillin-resistant coagulase-negative staphylococci and methicillin-susceptible Staphylococcus aureus strains occur frequently enough to represent a risk of false-positive methicillin-resistant S. aureus determinations by molecular methods?耐甲氧西林凝固酶阴性葡萄球菌和甲氧西林敏感金黄色葡萄球菌菌株的鼻腔共同定植是否频繁发生，足以构成通过分子方法测定耐甲氧西林金黄色葡萄球菌出现假阳性结果的风险？
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