姜黄素对载脂蛋白E/低密度脂蛋白受体双敲除小鼠动脉粥样硬化的影响。
Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice.
作者信息
Olszanecki R, Jawień J, Gajda M, Mateuszuk L, Gebska A, Korabiowska M, Chłopicki S, Korbut R
机构信息
Department of Histology, Jagiellonian University School of Medicine, Cracow, Poland.
出版信息
J Physiol Pharmacol. 2005 Dec;56(4):627-35.
It is widely appreciated that inflammation and oxidant stress contribute to atherogenesis. Curcumin, a polyphenolic natural compound has been reported to possess anti-inflammatory and anti-oxidant actions. We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR-double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid). Curcumin (purity>or=98%), premixed with diet, was given for 4 months at a dose of 0.3 mg/ per day/ per mouse. In this model curcumin inhibited atherogenesis, measured both by "en face" method (25,15+/-2,9% vs. 19,2+/-0,6%, p<0,05) and "cross-section" method (565867+/-39764 microm2 vs. 299201+/-20373 microm2, p<0,05). Importantly, curcumin influenced neither the concentrations of cholesterol and triglycerides in blood nor animal body weight. To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR-double knockout mice.
炎症和氧化应激促进动脉粥样硬化的发生，这一点已得到广泛认可。姜黄素是一种多酚类天然化合物，据报道具有抗炎和抗氧化作用。我们推测，姜黄素可以抑制喂食西式饮食（21%脂肪，0.15%胆固醇，重量比，不含胆酸）的载脂蛋白E/低密度脂蛋白受体双敲除小鼠动脉粥样硬化的发展。将姜黄素（纯度≥98%）与饮食预混合，以每天每只小鼠0.3毫克的剂量给予4个月。在该模型中，通过“正面”方法（25.15±2.9%对19.2±0.6%，p<0.05）和“横截面”方法（565867±39764平方微米对299201±20373平方微米，p<0.05）测量，姜黄素均抑制了动脉粥样硬化的发展。重要的是，姜黄素既不影响血液中胆固醇和甘油三酯的浓度，也不影响动物体重。据我们所知，这是首次报道低剂量姜黄素在动脉粥样硬化精细模型——基因靶向载脂蛋白E/低密度脂蛋白受体双敲除小鼠中具有抗动脉粥样硬化作用。
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