Frankfort Suzanne V, Tulner Linda R, van Campen Jos P C M, Koks Cornelis H W, Beijnen Jos H
Department of Geriatric Medicine, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands.
Pharmacoepidemiol Drug Saf. 2006 Aug;15(8):602-6. doi: 10.1002/pds.1195.
To investigate the changes in pharmacotherapy of patients during and after admission to a geriatric ward in 2002 and to investigate if this goes along with reduction of drugs. To describe the differences of the admitted patients and their medication in 2002 compared to 1985.
Included patients were admitted to the geriatric ward of a general hospital in the Netherlands during 2002 (n = 258, mean age 84.2 years). Medication at admission, during admission and at discharge were described after retrospective reviewing of medical charts. A comparable study was performed at the same ward in 1985.
In 2002, most frequently used medication at admission was acetylsalicylic acid (30.2%). Pantoprazole was during admission used in 38.8% of patients and at discharge in 31.8%. Folic acid that was at admission used by 11.6% of patients was at discharge increased to 23.4%. At discharge, vitamin D was used in 21.5% of patients, whereas lisinopril was used in 17.8% of patients. Both in 1985 and 2002 vitamins were added and use of antibiotics was increased during admission. A mean addition of 1.0 drug in 1985 and of 0.7 drugs in 2002 was observed.
Geriatric hospital admission resulted both in 1985 and 2002 in addition of medication. In both periods reductions in medication were nullified by addition of medication for reason of therapy optimisation. Compared to 1985 admitted patients receive more medication resulting from new insights into pharmacotherapy and more use of preventive medicine.
调查2002年老年病房患者住院期间及出院后的药物治疗变化情况,并调查这是否伴随着药物的减少。描述2002年与1985年相比入院患者及其用药情况的差异。
纳入的患者于2002年入住荷兰一家综合医院的老年病房(n = 258,平均年龄84.2岁)。通过回顾病历描述入院时、住院期间及出院时的用药情况。1985年在同一病房进行了一项类似研究。
2002年,入院时最常用的药物是阿司匹林(30.2%)。泮托拉唑在38.8%的患者住院期间使用,出院时为31.8%。入院时11.6%的患者使用叶酸,出院时增至23.4%。出院时,21.5%的患者使用维生素D,17.8%的患者使用赖诺普利。1985年和2002年住院期间均添加了维生素且抗生素使用增加。观察到1985年平均添加1.0种药物,2002年为0.7种药物。
1985年和2002年老年患者住院均导致用药增加。在这两个时期,由于治疗优化而添加药物抵消了用药的减少。与1985年相比,入院患者因药物治疗新见解及更多使用预防药物而服用更多药物。