Woo Sang-Hyuk, Ahn Hyo-Hyun, Kim Soo-Nam, Kye Young-Chul
Dept. of Dermatology, Korea University Anam Hospital, #126-1, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Korea.
Dermatol Surg. 2006 Jan;32(1):41-8. doi: 10.1111/1524-4725.2006.32005.
In the dermatology field, variable-pulse 595 nm pulsed dye lasers (PDLs) are now being widely used to treat vascular skin lesions. However, there is little information available on variable-pulse 595 nm PDL treatment of dark-skinned patients.
The objective of this study was to evaluate the outcome of variable-pulse 595 nm PDL treatment on Korean patients.
Two hundred thirty-nine patients (Fitzpatrick skin phototypes III to V) with vascular skin lesions, such as nevus flammeus, telangiectasia, or hemangioma, were included in this study. All patients were treated with a variable-pulse 595 nm PDL, and the outcomes were assessed by comparing preoperative and postoperative photographs.
The average number of treatments per patient was 4.29, and 51.9% of patients showed a good (51-75% clearance) to excellent (76-100% clearance) response. For nevus flammeus, 48.0% of the patients achieved good to excellent results. The gender and age of the patients did not influence the clinical response; however, lesions of the head and neck were found to respond more favorably to treatment. For telangiectasia, 78.0% of patients showed good to excellent results, and, again, the gender and age of the patients did not alter the treatment outcome. For hemangioma, the male to female ratio of patients was 1.0:3.1 and 54.1% of the patients achieved a good to excellent response. Superficial hemangioma showed a better clinical response than deep hemangioma, and the lesions of younger patients responded more favorably than those of older patients.
The variable-pulse 595 nm PDL was found to be effective for treating several vascular skin lesions in dark-skinned patients. However, there were differences in treatment outcome owing to disease, age, and the location of the lesions.
在皮肤科领域，可变脉冲595纳米脉冲染料激光（PDL）目前正被广泛用于治疗皮肤血管病变。然而，关于可变脉冲595纳米PDL治疗深色皮肤患者的信息很少。
本研究的目的是评估可变脉冲595纳米PDL治疗韩国患者的效果。
本研究纳入了239例患有血管性皮肤病变（如鲜红斑痣、毛细血管扩张或血管瘤）的患者（Fitzpatrick皮肤光类型III至V）。所有患者均接受可变脉冲595纳米PDL治疗，并通过比较术前和术后照片评估治疗效果。
每位患者的平均治疗次数为4.29次，51.9%的患者显示出良好（清除率51 - 75%）至优异（清除率76 - 100%）的反应。对于鲜红斑痣，48.0%的患者取得了良好至优异的效果。患者的性别和年龄不影响临床反应；然而，发现头颈部的病变对治疗反应更有利。对于毛细血管扩张，78.0%的患者显示出良好至优异的效果，并且患者的性别和年龄同样不改变治疗结果。对于血管瘤，患者的男女比例为1.0:3.1，54.1%的患者取得了良好至优异的反应。浅表血管瘤的临床反应优于深部血管瘤，年轻患者的病变比老年患者的病变反应更有利。
发现可变脉冲595纳米PDL对治疗深色皮肤患者的几种皮肤血管病变有效。然而，由于疾病、年龄和病变部位的不同，治疗效果存在差异。
