心肌梗死和心包积血死亡率的季节性变化。一项尸检研究。

Seasonal variation in mortality from myocardial infarction and haemopericardium. A postmortem study.

作者信息

Biedrzycki O, Baithun S

机构信息

The Royal London Hospital, Whitechapel Road, London E1 1BB, UK.

出版信息

J Clin Pathol. 2006 Jan;59(1):64-6. doi: 10.1136/jcp.2005.025965.

DOI:10.1136/jcp.2005.025965

PMID:16394282

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1860267/

Abstract

BACKGROUND

Seasonal variation in the incidence of and mortality from myocardial infarction (MI) has been well recognised for many years. Haemopericardium (HP) is usually a fatal complication of MI. No data exist in the literature with regard to the seasonal variation in mortality from HP.

AIMS

To perform a necropsy based study to confirm seasonal variation in mortality from MI in a London population and to determine whether seasonal variation in mortality from HP can be established.

METHODS

Postmortem causes of death issued by several pathologists, working in two public London mortuaries over a five year period from 1999 to 2004 were analysed. Deaths caused by HP secondary to traumatic or iatrogenic causes were specifically excluded, as were deaths caused by HP secondary to bicuspid aortic valve and aortic dissection. The results were subdivided into winter (1 November to 31 March) and summer (1 April to 31 October).

RESULTS

In total, there were 2266 cases of MI and 135 cases of HP. Significantly more deaths from HP (83 of 135; 61.5%; p = 0.004) and MI (1051 of 2266; 46.4%; p = 0.016) occurred in the five month winter period. Furthermore, there was a significantly higher incidence of HP compared with MI during the winter (83/1051; 7.9%) than the summer (52/1215; 4.3%; p<0.001). There was no significant difference in the age or sex of patients dying in either the winter or summer.

CONCLUSION

There is seasonal variation in mortality from both MI and HP in the London population, as confirmed by a postmortem study.

摘要

背景

心肌梗死（MI）发病率和死亡率的季节性变化多年来已得到充分认识。心包积血（HP）通常是MI的致命并发症。文献中尚无关于HP死亡率季节性变化的数据。

目的

进行一项基于尸检的研究，以证实伦敦人群中MI死亡率的季节性变化，并确定是否能确定HP死亡率的季节性变化。

方法

分析了1999年至2004年期间在伦敦两家公共太平间工作的几位病理学家发布的死后死因。特别排除了由创伤或医源性原因继发的HP导致的死亡，以及由二尖瓣主动脉瓣和主动脉夹层继发的HP导致的死亡。结果分为冬季（11月1日至3月31日）和夏季（4月1日至10月31日）。

结果

共有2266例MI和135例HP。在五个月的冬季，因HP死亡（135例中的83例；61.5%；p = 0.004）和因MI死亡（2266例中的1051例；46.4%；p = 0.016）的情况明显更多。此外，冬季HP的发病率（83/1051；7.9%）明显高于夏季（52/1215；4.3%；p<0.001）。冬季或夏季死亡患者的年龄和性别无显著差异。