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美国消防员的季节性与冠心病死亡情况

Seasonality and coronary heart disease deaths in United States firefighters.

作者信息

Mbanu Ibeawuchi, Wellenius Gregory A, Mittleman Murray A, Peeples Lynne, Stallings Leonard A, Kales Stefanos N

机构信息

Department of Environmental Health (Occupational Health Program), Harvard School of Public Health, Boston, MA, USA.

出版信息

Chronobiol Int. 2007;24(4):715-26. doi: 10.1080/07420520701535787.

Abstract

United States firefighters have a high on-duty fatality rate, and coronary heart disease is the leading cause. Seasonality affects the incidence of cardiovascular events in the general population, but its effects on firefighters are unknown. This study statistically examined the seasonal and annual variation of all on-duty coronary heart disease deaths among US firefighters between 1994 and 2004 using the chi-square distribution and Poisson regression model of the monthly fatality counts. It also examined the effect of ambient temperature (apparent as well as wind chill temperature) on coronary heart disease fatalities during the study span using a time-stratified, case-crossover study design. When grouped by season, we observed the distribution of the 449 coronary heart disease fatalities to show a relative peak in winter (32%) and relative nadir in spring (21%). This pattern was significantly different (p=0.005) from the expected distribution under the null hypothesis of season having no effect. The pattern persisted in additional analyses, stratifying the deaths by the type of duty in which the firefighters were engaged at the time of their deaths. In the Poisson regression model of the monthly fatality counts, the overall goodness-of-fit between the actual and predicted case counts was excellent (chi(4)(2)=16.63; p=0.002). Two distinct peaks were detected: one in January-February and the other in August-September. Overall temperature was not associated with increased risk of on-duty death. After allowing for different effects of temperature in mild/hot versus cold periods, a 1 degrees C increase was not protective in cold weather; nor did it increase the risk of death in warmer weather. The findings of this study reveal statistical evidence for excess coronary heart disease deaths among firefighters during winter; however, the temporal pattern of coronary heart disease deaths was not linked to temperature variation. The seasonal pattern was also found to be independent of duty-related risks.

摘要

美国消防员在职死亡率很高,冠心病是主要死因。季节性会影响普通人群中心血管事件的发生率,但其对消防员的影响尚不清楚。本研究使用每月死亡人数的卡方分布和泊松回归模型,对1994年至2004年间美国消防员所有在职冠心病死亡的季节性和年度变化进行了统计分析。研究还采用时间分层的病例交叉研究设计,考察了研究期间环境温度(表观温度以及风寒温度)对冠心病死亡的影响。按季节分组时,我们观察到449例冠心病死亡的分布情况显示,冬季相对峰值为32%,春季相对谷底为21%。这种模式与季节无影响的零假设下的预期分布显著不同(p=0.005)。在进一步分析中,按消防员死亡时所从事的工作类型对死亡进行分层,该模式依然存在。在每月死亡人数的泊松回归模型中,实际病例数与预测病例数之间的整体拟合优度极佳(χ(4)(2)=16.63;p=0.002)。检测到两个不同的峰值:一个在1月至2月,另一个在8月至9月。总体温度与在职死亡风险增加无关。在考虑了温和/炎热期与寒冷期温度的不同影响后,气温每升高1摄氏度在寒冷天气中并无保护作用;在温暖天气中也不会增加死亡风险。本研究结果揭示了消防员在冬季冠心病死亡过多的统计证据;然而,冠心病死亡的时间模式与温度变化无关。还发现季节性模式与工作相关风险无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2870/3756551/5be0b5034f5e/nihms46652f1.jpg

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