胺碘酮毒性表现为肺部肿块和周围神经病变：持续存在的诊断挑战。
Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge.
作者信息
Azzam I, Tov N, Elias N, Naschitz J E
机构信息
Department of Internal Medicine A, Bnai-Zion Medical Centre and Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
Postgrad Med J. 2006 Jan;82(963):73-5. doi: 10.1136/pgmj.2005.040105.
Abstract
A 64 year old man receiving long term amiodarone treatment presented with dyspnea, cough, and weight loss. Radiographs and computed tomography showed a lung mass with associated multiple pulmonary nodules. Biopsies of the pulmonary mass showed foamy histiocytes without malignant cells. However, findings on FDG-PET scan were consistent with a malignant tumour. These findings on computed tomography and PET scan and the unusually late resolution of the pulmonary lesions after withdrawal of amiodarone treatment posed a challenging diagnostic problem.
摘要
一名接受长期胺碘酮治疗的64岁男性出现呼吸困难、咳嗽和体重减轻。X光片和计算机断层扫描显示肺部有肿块及多个相关肺结节。肺部肿块活检显示为泡沫状组织细胞，未见恶性细胞。然而，氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）结果与恶性肿瘤相符。计算机断层扫描和PET扫描的这些结果，以及胺碘酮停药后肺部病变异常延迟消退的情况，构成了一个具有挑战性的诊断难题。
相似文献
1
Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge.
Postgrad Med J. 2006 Jan;82(963):73-5. doi: 10.1136/pgmj.2005.040105.
2
Amiodarone-induced pulmonary toxicity in an adolescent.
Cardiol Young. 1999 Mar;9(2):194-6. doi: 10.1017/s1047951100008441.
3
Amiodarone-related pneumonitis and peripheral neuropathy in an elderly patient.
Aging Clin Exp Res. 2010 Oct-Dec;22(5-6):466-9. doi: 10.1007/BF03324945.
4
[Peripheral neuropathy and amiodarone].
Aten Primaria. 2000 Apr 15;25(6):450-2.
5
An enlarged heart with hyperdense consolidation.
Neth J Med. 2013 Jul-Aug;71(6):317, 321.
6
Amiodarone-induced pulmonary toxicity.
CMAJ. 2012 Oct 16;184(15):E819. doi: 10.1503/cmaj.111763. Epub 2012 Apr 23.
7
[Late postoperative amiodarone pulmonary toxicity].
An Med Interna. 2003 Aug;20(8):419-20.
8
Recurrent amiodarone pulmonary toxicity.
South Med J. 1996 Jan;89(1):85-6. doi: 10.1097/00007611-199601000-00016.
9
An uncommon tomographic association: amiodarone pulmonary toxicity and adenocarcinoma.
J Bras Pneumol. 2016 Nov-Dec;42(6):465. doi: 10.1590/S1806-37562016000000168.
10
HRCT findings of amiodarone pulmonary toxicity: clinical and radiologic regression.
J Cardiovasc Pharmacol Ther. 2001 Jul;6(3):307-11. doi: 10.1177/107424840100600311.
引用本文的文献
1
Amiodarone Therapy: Updated Practical Insights.
J Clin Med. 2024 Oct 12;13(20):6094. doi: 10.3390/jcm13206094.
2
A multicenter retrospective cohort study on predicting the risk for amiodarone pulmonary toxicity.
BMC Pulm Med. 2022 Apr 5;22(1):128. doi: 10.1186/s12890-022-01926-y.
3
Nodules that Wax and Wane: Unusual Presentation of Amiodarone Lung Toxicity.
Cureus. 2020 Jul 8;12(7):e9058. doi: 10.7759/cureus.9058.
4
Adverse reactions of Amiodarone.
J Geriatr Cardiol. 2019 Jul;16(7):552-566. doi: 10.11909/j.issn.1671-5411.2019.07.004.
5
Challenges of thyroid cancer management in amiodarone-treated patients: a case report.
Clujul Med. 2015;88(4):550-4. doi: 10.15386/cjmed-502. Epub 2015 Nov 15.
6
Antiarrhythmic agents and the risk of malignant neoplasm of liver and intrahepatic bile ducts.
PLoS One. 2015 Jan 15;10(1):e0116960. doi: 10.1371/journal.pone.0116960. eCollection 2015.
7
[Medical therapy of heart and lung diseases. Effects on the respective other organ].
Herz. 2014 Feb;39(1):15-24. doi: 10.1007/s00059-013-4035-4.
8
Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect?
Clin Res Cardiol. 2010 Nov;99(11):693-700. doi: 10.1007/s00392-010-0181-3. Epub 2010 Jul 10.
9
Amiodarone pulmonary toxicity.
Can Respir J. 2009 Mar-Apr;16(2):43-8. doi: 10.1155/2009/282540.
10
Hemokinins and endokinins.
Cell Mol Life Sci. 2004 Jul;61(13):1652-63. doi: 10.1007/s00018-004-4035-x.
本文引用的文献
1
Lung masses in a 70-year-old man.
Chest. 2005 Apr;127(4):1433-6. doi: 10.1378/chest.127.4.1433.
2
Exogenous lipoid pneumonia with unusual CT pattern and FDG positron emission tomography scan findings.
Eur Radiol. 2002 Dec;12 Suppl 3:S171-3. doi: 10.1007/s00330-002-1659-9. Epub 2002 Oct 1.
3
Pulmonary nodules with the CT halo sign.
Respiration. 2002;69(1):103-6. doi: 10.1159/000049381.
4
Pulmonary mass and multiple lung nodules mimicking a lung neoplasm as amiodarone-induced pulmonary toxicity.
Eur J Intern Med. 2001 Jul;12(4):372-376. doi: 10.1016/s0953-6205(01)00127-3.
5
Multivesiculated macrophages: their implication in fine-needle aspiration cytology of lung mass lesions.
Diagn Cytopathol. 1998 Aug;19(2):98-101. doi: 10.1002/(sici)1097-0339(199808)19:2<98::aid-dc5>3.0.co;2-j.
6
Comparison of the Bayesian approach and a simple algorithm for assessment of adverse drug events.
Clin Pharmacol Ther. 1995 Dec;58(6):692-8. doi: 10.1016/0009-9236(95)90026-8.
7
Amiodarone.
N Engl J Med. 1987 Feb 19;316(8):455-66. doi: 10.1056/NEJM198702193160807.
8
Amiodarone pulmonary toxicity presenting as a solitary lung mass.
Chest. 1988 Feb;93(2):425-7. doi: 10.1378/chest.93.2.425.
9
Atypical pulmonary and neurologic complications of amiodarone in the same patient. Report of a case and review of the literature.
Arch Intern Med. 1987 Oct;147(10):1805-9.
10
Amiodarone-induced pulmonary mass.
Ann Thorac Surg. 1989 Jun;47(6):918-9. doi: 10.1016/0003-4975(89)90037-4.
Zotero 插件