Arata Sayaka, Ohmi Aki, Mizukoshi Fuminori, Baba Kenji, Ohno Koichi, Setoguchi Asuka, Tsujimoto Hajime
Depertment of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
J Vet Med Sci. 2005 Dec;67(12):1253-5. doi: 10.1292/jvms.67.1253.
Transforming growth factor-beta1 (TGF-beta1), an inflammatory cytokine, plays a role in tissue fibrosis, such as glomerular sclerosis and tubulointerstitial fibrosis of the kidneys. In the present study, the urinary TGF-beta1 level of cats diagnosed with chronic renal failure (CRF) was measured to investigate its relationship to the pathogenesis of feline CRF. Urinary TGF-beta1 levels (TGF-beta1/creatinine ratio) were significantly increased compared with healthy controls, whereas serum levels of TGF-beta1 were not. These results indicate that TGF-beta1 is expressed in the kidneys of CRF cats, and that it was reflected in the urinary TGF-beta1 level. Therefore, TGF-beta1 may play a role in feline CRF, and urinary TGF-beta1 could be used as a clinical marker for renal fibrosis.
转化生长因子-β1（TGF-β1）是一种炎性细胞因子，在组织纤维化中发挥作用，如肾脏的肾小球硬化和肾小管间质纤维化。在本研究中，测量了被诊断为慢性肾衰竭（CRF）的猫的尿TGF-β1水平，以研究其与猫CRF发病机制的关系。与健康对照组相比，尿TGF-β1水平（TGF-β1/肌酐比值）显著升高，而血清TGF-β1水平则无变化。这些结果表明，TGF-β1在CRF猫的肾脏中表达，并反映在尿TGF-β1水平上。因此，TGF-β1可能在猫CRF中起作用，尿TGF-β1可作为肾纤维化的临床标志物。
