Mukherjee M, Das A S, Das D, Mukherjee S, Mitra S, Mitra C
Department of Physiology, Presidency College, Kolkata-700073, India.
Phytother Res. 2006 Jan;20(1):21-7. doi: 10.1002/ptr.1795.
The purpose of this study was to examine the antiosteoporosis effects of garlic oil in an ovariectomized (Ovx) rat model of osteoporosis and to compare its efficacy with lovastatin (a synthetic hypocholesterolemic drug) and 17beta-estradiol (a potent antiosteoporotic agent). Animals were divided into five groups: sham-operated control, ovariectomized, ovariectomized supplemented with lovastatin, ovariectomized supplemented with garlic oil and ovariectomized supplemented with 17beta-estradiol. In our study, the development of a high rate of bone turnover and osteoporosis in the ovariectomized animals were confirmed by significant alterations of serum alkaline phosphatase activity, serum tartrate-resistant acid phosphatase activity, urinary excretion of calcium, phosphate, hydroxyproline and urinary calcium to creatinine ratio, when compared with the sham-operated control group. Supplementation of these animals with either garlic oil or lovastatin or 17beta-estradiol, in addition to their hypocholesterolemic effect, could counterbalance all these changes. The results revealed that all three compounds significantly protected the hypogonadal bone loss as reflected by higher bone densities and higher bone mineral contents than the ovariectomized group of animals. The results emphasize that, like 17beta-estradiol, the hypocholesterolemic compounds garlic oil and lovastatin are also effective in suppressing bone loss owing to estrogen deficiency and their efficacy in the order of lower to higher is garlic < lovastatin < 17beta-estradiol.
本研究的目的是在去卵巢（Ovx）骨质疏松大鼠模型中检测大蒜油的抗骨质疏松作用，并将其疗效与洛伐他汀（一种合成的降胆固醇药物）和17β-雌二醇（一种有效的抗骨质疏松剂）进行比较。动物被分为五组：假手术对照组、去卵巢组、去卵巢补充洛伐他汀组、去卵巢补充大蒜油组和去卵巢补充17β-雌二醇组。在我们的研究中，与假手术对照组相比，血清碱性磷酸酶活性、血清抗酒石酸酸性磷酸酶活性、尿钙、磷、羟脯氨酸排泄量以及尿钙与肌酐比值的显著变化证实了去卵巢动物中高骨转换率和骨质疏松的发展。给这些动物补充大蒜油、洛伐他汀或17β-雌二醇，除了具有降胆固醇作用外，还可以抵消所有这些变化。结果显示，与去卵巢动物组相比，所有三种化合物都能显著保护性腺功能减退导致的骨质流失，表现为更高的骨密度和更高的骨矿物质含量。结果强调，与17β-雌二醇一样，降胆固醇化合物大蒜油和洛伐他汀在抑制因雌激素缺乏引起的骨质流失方面也有效，其疗效从低到高依次为大蒜<洛伐他汀<17β-雌二醇。
