Mukherjee Maitrayee, Das Asankur Sekhar, Das Dolan, Mukherjee Sandip, Mitra Smita, Mitra Chandan
Department of Physiology, Presidency College, Kolkata, India.
Phytother Res. 2006 May;20(5):408-15. doi: 10.1002/ptr.1888.
The present study was undertaken to examine the effects of an oil extract of garlic on the in vivo intestinal transference of calcium, and also to verify its role in maintaining the bone mineral content and bone tensile strength in an ovariectomized rat model of osteoporosis. The results suggest that, in this experimental model, oil extract of garlic promotes intestinal transference of calcium by modulating the activities of both intestinal alkaline phosphatase and Ca(2+) activated ATPase. Also the observed low bone mineral content and low bone tensile strength in these rats were significantly restored by garlic oil supplementation. Further, garlic oil supplementation was able to revive partially the bilateral ovariectomy-induced decrease in the serum estrogen titer. The serum parathyroid hormone level, however, was found unaltered in these rats. The garlic oil supplemented partial recovery in serum estrogen titer in bilaterally ovariectomized rat was found to be persistently associated with enhanced calcium transference and better preservation of bone mineral content. The results of this study propose that the phytoestrogenic efficacy of an oil extract of garlic prevents ovarian hormone deficiency induced bone mineral loss possibly by promoting intestinal transference of calcium through the partial revival of the serum estrogen titer.
本研究旨在探讨大蒜油提取物对体内钙肠道转运的影响，并验证其在去卵巢骨质疏松大鼠模型中维持骨矿物质含量和骨拉伸强度的作用。结果表明，在该实验模型中，大蒜油提取物通过调节肠道碱性磷酸酶和Ca(2+)激活的ATP酶的活性来促进钙的肠道转运。此外，补充大蒜油可显著恢复这些大鼠低骨矿物质含量和低骨拉伸强度的状况。此外，补充大蒜油能够部分恢复双侧卵巢切除引起的血清雌激素滴度下降。然而，这些大鼠的血清甲状旁腺激素水平未发生改变。在双侧去卵巢大鼠中，补充大蒜油后血清雌激素滴度的部分恢复与钙转运增强和骨矿物质含量的更好保存持续相关。本研究结果表明，大蒜油提取物的植物雌激素功效可能通过部分恢复血清雌激素滴度促进钙的肠道转运，从而预防卵巢激素缺乏引起的骨矿物质流失。
