Kubota Y, Imayama S, Hori Y
Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Dermatol. 1992 Mar;19(3):177-80. doi: 10.1111/j.1346-8138.1992.tb03202.x.
During a series of studies on the involvement of house dust mite antigens in 183 cases of atopic dermatitis, we observed an improvement in two patients following the removal of mites from their environment by means of a thorough housecleaning and replacement of the mattress. Both patients manifested the typical clinical skin lesions of atopic dermatitis and had similar laboratory findings. Although the serum IgE concentrations and specific IgE to Dermatophagoides pteronyssinus and Dermatophagoides farinae were each relatively low, the results of patch tests with these antigens were positive. Thus, a regimen aimed at reducing the presence of house dust mites can produce clinical improvement in a subset of patients with atopic dermatitis who show contact hypersensitivity to mite antigens on skin testing, but negative results on IgE (RAST; radioallergosorbent technique) testing.
在对183例特应性皮炎患者进行的一系列关于屋尘螨抗原参与情况的研究中，我们观察到两名患者通过彻底清洁房屋和更换床垫清除环境中的螨虫后病情有所改善。两名患者均表现出特应性皮炎典型的临床皮肤损害，且实验室检查结果相似。尽管血清IgE浓度以及针对粉尘螨和屋尘螨的特异性IgE相对较低，但这些抗原的斑贴试验结果呈阳性。因此，旨在减少屋尘螨存在的方案可使一部分特应性皮炎患者的病情得到临床改善，这些患者皮肤试验显示对螨抗原存在接触性超敏反应，但IgE（放射性变应原吸附试验；RAST）检测结果为阴性。
