Jiang Y-D, Yen C-J, Chou W-L, Kuo S-S, Lee K-C, Chiu K C, Chuang L-M
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Diabet Med. 2005 Dec;22(12):1690-5. doi: 10.1111/j.1464-5491.2005.01715.x.
Apolipoprotein AV (APOA5) is an important determinant of plasma triglyceride concentration. This study aimed to investigate the relationship of an amino acid substitution at position 182 (G182C) of the apolipoprotein AV (APOA5) gene with triglyceride concentration in a Taiwanese population.
This study enrolled two cohorts: non-diabetic subjects (112 males and 89 females) aged 50.3+/-11.0 years (mean+/-sd) and diabetic subjects (106 males and 96 females) aged 62.1+/-10.3 years. The relationship between the G182C polymorphism (rs 2075291) and plasma triglycerides was examined. Demographic and metabolic parameters including age, sex, body mass index, fasting plasma glucose and total cholesterol were also obtained.
The G182C polymorphism was a determinant of plasma triglycerides in both non-diabetic (P=0.022) and diabetic (P=0.003) groups, independent of age, gender, fasting plasma glucose, body mass index and total cholesterol. In the diabetic group, this genetic polymorphism interacts significantly (P=0.032) with fasting plasma glucose concentration on plasma triglycerides after adjustment for age, sex, body mass index and total cholesterol.
In conclusion, the G182C polymorphism of the APOA5 gene affects plasma triglycerides in both non-diabetic and diabetic populations. The observed interaction of gene and glycaemic control further indicates a multifactorial nature of clinical phenotypes in subjects with Type 2 diabetes.
载脂蛋白AV（APOA5）是血浆甘油三酯浓度的重要决定因素。本研究旨在探讨台湾人群中载脂蛋白AV（APOA5）基因第182位氨基酸替换（G182C）与甘油三酯浓度之间的关系。
本研究纳入了两个队列：年龄为50.3±11.0岁（均值±标准差）的非糖尿病受试者（112名男性和89名女性）以及年龄为62.1±10.3岁的糖尿病受试者（106名男性和96名女性）。检测了G182C多态性（rs 2075291）与血浆甘油三酯之间的关系。还获取了包括年龄、性别、体重指数、空腹血糖和总胆固醇在内的人口统计学和代谢参数。
在非糖尿病组（P = 0.022）和糖尿病组（P = 0.003）中，G182C多态性都是血浆甘油三酯的决定因素，且独立于年龄、性别、空腹血糖、体重指数和总胆固醇。在糖尿病组中，在调整年龄、性别、体重指数和总胆固醇后，这种基因多态性与空腹血糖浓度在影响血浆甘油三酯方面存在显著相互作用（P = 0.032）。
总之，APOA5基因的G182C多态性在非糖尿病和糖尿病人群中均影响血浆甘油三酯。观察到的基因与血糖控制之间的相互作用进一步表明2型糖尿病患者临床表型具有多因素性质。
