Lebeau Thierry, Perrotte Paul, Valiquette Luc, Bénard François, McCormack Michael, Saad Fred, Karakiewicz Pierre I
Department of Urology, University of Montreal, Montreal, Quebec, Canada.
Can J Urol. 2005 Dec;12(6):2873-9.
Assessment of prostate cancer (PCa) specific and generic health-related quality-of-life (HRQOL) is frequently omitted due to several obstacles, such as respondent burden and infrastructure-related limitations. We attempted to reduce the number of items of two commonly used HRQOL assessment tools, namely the UCLA PCa Index (PCI) and the RAND SF-12, with the intent of generating the most parsimonious, yet psychometrically valid and reliable HRQOL assessment tool.
The PCI and SF-12 were administered to 2415 radical prostatectomy patients, and re-tested in a convenience sample of 35 men with PCa. Multivariate linear regression models defined the most predictive and item-reduced SF-12 and PCI item combinations. These were subjected to standard psychometric reliability and validity tests.
The 8-item PCI sexual function (SF) scale was reduced to three items. The 5-item PCI urinary function (UF) scale was reduced to three items. The 6-item SF-12 mental health scale was reduced to three items, and the 6-item SF-12 physical scale was also reduced to three items. The total number of items was reduced from 27 to 12 (44%). The item-reduced scales accounted for over 85% of full-scale variance. All reliability and validity tests yielded highly satisfactory results.
We developed SF-12 and PCI short-forms, which consist of 12 of 27 (44%) original items and can be completed by most men within 2 minutes. The short-forms represent a valid substitute for the full scales, as they provide over 85% of full-scale information and demonstrate excellent reliability statistics. The short forms have the potential for decreasing respondent burden and infrastructure-related requirements, which may in turn promote HRQOL assessment after radical prostatectomy.
由于诸多障碍，如受访者负担和基础设施相关限制，前列腺癌（PCa）特异性和一般健康相关生活质量（HRQOL）的评估常常被省略。我们试图减少两种常用HRQOL评估工具（即加州大学洛杉矶分校前列腺癌指数（PCI）和兰德SF - 12）的条目数量，旨在生成最简洁、但在心理测量学上有效且可靠的HRQOL评估工具。
对2415例接受根治性前列腺切除术的患者进行PCI和SF - 12评估，并在35例PCa患者的便利样本中进行重新测试。多变量线性回归模型确定了最具预测性且条目减少的SF - 12和PCI条目组合。对这些组合进行标准心理测量学可靠性和有效性测试。
8项PCI性功能（SF）量表减少至3项。5项PCI排尿功能（UF）量表减少至3项。6项SF - 12心理健康量表减少至3项，6项SF - 12身体量表也减少至3项。条目总数从27项减少至12项（减少了44%）。条目减少后的量表占全量表方差的85%以上。所有可靠性和有效性测试均产生了非常令人满意的结果。
我们开发了SF - 12和PCI简表，它们由27项中的12项（44%）原始条目组成，大多数男性可在2分钟内完成。简表可有效替代全量表，因为它们提供了超过85%的全量表信息，并展示了出色的可靠性统计数据。简表有可能减轻受访者负担和与基础设施相关的要求，这反过来可能会促进根治性前列腺切除术后的HRQOL评估。
