吉兰-巴雷综合征中的异位骨化：发病率及长期随访对功能预后的影响
Heterotopic ossification in Guillain-Barré syndrome: incidence and effects on functional outcome with long-term follow-up.
作者信息
Zeilig Gabi, Weingarden Harold P, Levy Richard, Peer Inbal, Ohry Avi, Blumen Nava
机构信息
Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer; and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
出版信息
Arch Phys Med Rehabil. 2006 Jan;87(1):92-5. doi: 10.1016/j.apmr.2005.07.308.
OBJECTIVE
To define the incidence, effects on functional abilities, and possible causation of heterotopic ossification (HO) in Guillain-Barré syndrome (GBS) patients admitted for inpatient rehabilitation.
DESIGN
Long-term prospective study on neurologic and functional outcome of GBS patients admitted for rehabilitation.
SETTING
Rehabilitation department, inpatient and outpatient, within a university-affiliated medical center.
PARTICIPANTS
All GBS patients admitted for rehabilitation and followed for a minimum of 3 years.
INTERVENTIONS
Not applicable.
MAIN OUTCOME MEASURES
Presence of HO, factors that may be etiologically significant, and effects on functionality. Data included: medical interventions, Disability Grading Scale, need for assisted ventilation, electrodiagnostic findings, autonomic function, standard neuro-musculo-skeletal evaluation, and hospital length of stay.
RESULTS
Four (6%) of 65 patients had HO, 24 of whom required mechanical ventilation. All had decreased range of motion in the involved hips that affected mobility.
CONCLUSIONS
Even though it has been rarely reported, HO does occur in GBS and affects functional outcome.
目的
确定因住院康复而收治的吉兰-巴雷综合征（GBS）患者中异位骨化（HO）的发生率、对功能能力的影响及可能的病因。
设计
对因康复而收治的GBS患者的神经和功能结局进行长期前瞻性研究。
地点
大学附属医院的康复科，包括住院部和门诊部。
参与者
所有因康复而收治且随访至少3年的GBS患者。
干预措施
不适用。
主要结局指标
HO的存在情况、可能具有病因学意义的因素以及对功能的影响。数据包括：医疗干预、残疾分级量表、辅助通气需求、电诊断结果、自主神经功能、标准神经肌肉骨骼评估以及住院时间。
结果
65例患者中有4例（6%）发生HO，其中24例需要机械通气。所有患者受累髋关节的活动范围均减小，影响了活动能力。
结论
尽管HO在GBS中鲜有报道，但确实会发生且会影响功能结局。
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