Zeilig Gabi, Weingarden Harold P, Levy Richard, Peer Inbal, Ohry Avi, Blumen Nava
Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer; and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
Arch Phys Med Rehabil. 2006 Jan;87(1):92-5. doi: 10.1016/j.apmr.2005.07.308.
To define the incidence, effects on functional abilities, and possible causation of heterotopic ossification (HO) in Guillain-Barré syndrome (GBS) patients admitted for inpatient rehabilitation.
Long-term prospective study on neurologic and functional outcome of GBS patients admitted for rehabilitation.
Rehabilitation department, inpatient and outpatient, within a university-affiliated medical center.
All GBS patients admitted for rehabilitation and followed for a minimum of 3 years.
Not applicable.
Presence of HO, factors that may be etiologically significant, and effects on functionality. Data included: medical interventions, Disability Grading Scale, need for assisted ventilation, electrodiagnostic findings, autonomic function, standard neuro-musculo-skeletal evaluation, and hospital length of stay.
Four (6%) of 65 patients had HO, 24 of whom required mechanical ventilation. All had decreased range of motion in the involved hips that affected mobility.
Even though it has been rarely reported, HO does occur in GBS and affects functional outcome.
确定因住院康复而收治的吉兰-巴雷综合征（GBS）患者中异位骨化（HO）的发生率、对功能能力的影响及可能的病因。
对因康复而收治的GBS患者的神经和功能结局进行长期前瞻性研究。
大学附属医院的康复科，包括住院部和门诊部。
所有因康复而收治且随访至少3年的GBS患者。
不适用。
HO的存在情况、可能具有病因学意义的因素以及对功能的影响。数据包括：医疗干预、残疾分级量表、辅助通气需求、电诊断结果、自主神经功能、标准神经肌肉骨骼评估以及住院时间。
65例患者中有4例（6%）发生HO，其中24例需要机械通气。所有患者受累髋关节的活动范围均减小，影响了活动能力。
尽管HO在GBS中鲜有报道，但确实会发生且会影响功能结局。
