Aldhilan Mansour M, Alshahrani Abdullah H
Department of Orthopedic Surgery, Ar Rass General Hospital, Ar Rass.
Department of Orthopedic Surgery, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Ann Med Surg (Lond). 2024 Jun 26;86(9):5509-5512. doi: 10.1097/MS9.0000000000002312. eCollection 2024 Sep.
Heterotopic ossification (HO) is the formation of bone within the soft tissues. It can be a complication of Guillain-Barre syndrome (GBS). There are many risk factors for HO, including male sex, mechanical ventilation, and neurogenic trauma. Myelin and axons are the main targets and areas of injury in GBS, an autoimmune-inflammatory neuropathy. Literature shows that this may possibly be associated with the initial administration of the COVID-19 vaccine and GBS.
A 27-year-old male was diagnosed with bile reflux gastritis. Days later, he presented to the emergency room (ER) with progressive weakness and a critical condition that required ICU. The patient undergoes intubation and remains in the ICU for 4 months. The patient, after extensive rehabilitation, started to complain of left hip pain and limitations of motion. Radiographs confirmed the HO diagnosis. Past drug history showed patients received a single dose of the COVID-19 vaccine 15 days before presentation to the ER.
There is no clear association between the COVID-19 vaccination and GBS. HO is the formation of abnormal bone within soft tissue. HO post-GBS usually affects large joints like the hips, knees, and shoulders. Researchers poorly understand the pathogenesis of GBS.
Despite the absence of a definitive correlation between GSB and the COVID-19 vaccine. Physicians should maintain a state of suspicion while treating patients with a progressive weakness. Additional research is required.
异位骨化（HO）是指在软组织内形成骨组织。它可能是吉兰 - 巴雷综合征（GBS）的一种并发症。HO有许多危险因素，包括男性、机械通气和神经源性创伤。髓鞘和轴突是GBS（一种自身免疫性炎性神经病）的主要损伤靶点和区域。文献表明，这可能与COVID - 19疫苗的初次接种和GBS有关。
一名27岁男性被诊断为胆汁反流性胃炎。数天后，他因进行性肌无力且病情危急被送往急诊室，需要入住重症监护病房（ICU）。患者接受了插管，并在ICU中停留了4个月。经过广泛康复治疗后，患者开始抱怨左髋疼痛和活动受限。X线片证实了HO的诊断。既往用药史显示患者在前往急诊室就诊前15天接种了一剂COVID - 19疫苗。
COVID - 19疫苗接种与GBS之间没有明确的关联。HO是软组织内异常骨的形成。GBS后的HO通常影响髋、膝和肩等大关节。研究人员对GBS的发病机制了解甚少。
尽管GBS与COVID - 19疫苗之间没有明确的相关性，但医生在治疗进行性肌无力患者时应保持怀疑态度。还需要进一步的研究。
