来自珊瑚的西松烷型二萜和一种刺囊烷型二萜

Cembranoid diterpenes and a briarane diterpene from corals.

作者信息

Grote Daniela, Soliman Hesham S M, Shaker Kamel H, Hamza Mohamed, Seifert Karlheinz

机构信息

University of Bayreuth, Organic Chemistry, NW II, D-95440 Bayreuth, Germany.

出版信息

Nat Prod Res. 2006 Mar;20(3):285-91. doi: 10.1080/14786410500087657.

DOI:10.1080/14786410500087657

PMID:16401561

Abstract

Two new cembrane diterpenes (+)-polydactylide (1) and (+)-7alpha,8beta-dihydroxydeepoxysarcophine (2) together with (+)-sarcophine (3) and (+)-sarcophytoxide (4) have been isolated from the soft coral Sinularia polydactyla. The new cembrane diterpene (-)-7beta-hydroxy-8alpha-methoxydeepoxysarcophine (5) has been obtained from the soft coral Sarcophyton trocheliophorum and the known briarane diterpene briaexcavatolide W (6) from the gorgonian coral Briareum sp.The structures were determined primarily by NMR spectroscopy. The assignment of NMR signals was performed by means of (1)H-(1)H COSY, ROESY, HMQC and HMBC experiments.

摘要

从软珊瑚多指肉芝软珊瑚中分离出了两种新的西松烷二萜（+）-多指内酯（1）和（+）-7α，8β-二羟基去氧 sarcophine（2），以及（+）-sarcophine（3）和（+）-sarcophytoxide（4）。新的西松烷二萜（-）-7β-羟基-8α-甲氧基去氧 sarcophine（5）是从软珊瑚瘤肉芝软珊瑚中获得的，而已知的荜澄茄烷二萜 briaexcavatolide W（6）是从柳珊瑚属珊瑚中获得的。这些结构主要通过核磁共振光谱法确定。核磁共振信号的归属通过（1）H-（1）H COSY、ROESY、HMQC 和 HMBC 实验进行。