Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Center, Dokki Cairo 12622, Egypt.
Mar Drugs. 2012 Jan;10(1):209-222. doi: 10.3390/md10010209. Epub 2012 Jan 18.
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
从红海软珊瑚 Sarcophyton glaucum 的乙酸乙酯提取物中进行的化学研究导致了两种过氧化物二萜的分离，即 11(S)过氧代鲨烯-12(20)-烯（1）和 12(S)-过氧代鲨烯-10-烯（2），以及 8-表鲨烯酮（3）。除了这三种新化合物外，还鉴定出了两种已知结构，包括：ent-鲨烯酮（4）和鲨烯酮（5）。通过光谱分析阐明了结构，通过 X 射线衍射确定了 1 和 2 的相对构型。分离出的化合物被发现是细胞色素 P₄₅₀ 1A 活性的抑制剂，也是谷胱甘肽 S-转移酶（GST）、醌还原酶（QR）和环氧化物水解酶（mEH）的诱导剂，为这些特征代谢物建立了化学预防和肿瘤抗起始活性。
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