Yang Qi-Bin, Wu Qihao, Chen Jun-Kun, Liang Lin-Fu
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Department of Chemistry, Yale University, New Haven, CT 06520, USA.
Mar Drugs. 2022 Dec 29;21(1):30. doi: 10.3390/md21010030.
The soft coral , which was frequently encountered on Indo-Pacific and Red Sea coral reefs, furnished a wealth of secondary metabolites. Notably, terpenoids dominated the chemical profile of this species. In this review, we summarized the discovery of 156 terpenoids from the soft coral specimens in different geographical areas. The structures comprised 13 terpenoidal classes with various functionalities. We covered the era from the first report of -derived metabolites in 1976 up to October 2022. The biological effects of these chemical compositions on a vast array of potential pharmacological activities such as protein tyrosine phosphatase 1B (PTP1B) inhibitory, neuroprotective, cytotoxic, anti-inflammatory, antibacterial, antivirus, and immunomodulatory activities were also presented. This review also revealed an immense demand to explore the terpene biosynthetic gene clusters of this species besides the chemo- and bio-investigations.
这种软珊瑚常见于印度-太平洋和红海的珊瑚礁，产生了大量次生代谢产物。值得注意的是，萜类化合物在该物种的化学组成中占主导地位。在本综述中，我们总结了从不同地理区域的软珊瑚标本中发现的156种萜类化合物。其结构包括13类具有各种官能团的萜类化合物。我们涵盖了从1976年首次报道该软珊瑚衍生代谢产物到2022年10月的这一时期。还介绍了这些化学成分对一系列潜在药理活性的生物学效应，如蛋白酪氨酸磷酸酶1B（PTP1B）抑制、神经保护、细胞毒性、抗炎、抗菌、抗病毒和免疫调节活性。本综述还表明，除了化学和生物学研究之外，对探索该物种的萜类生物合成基因簇也有巨大需求。
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