Yaegaki K, Sanada K
Department of Preventive and Community Dentistry, School of Dentistry, Niigata, Japan.
J Periodontal Res. 1992 Jul;27(4 Pt 1):233-8. doi: 10.1111/j.1600-0765.1992.tb01673.x.
Volatile sulfur compounds (VSC) in mouth air were estimated by gas chromatography. The amount of VSC and the methyl mercaptan/hydrogen sulfide ratio were significantly increased in patients with periodontal disease. These two parameters also increased in proportion to the bleeding index and probing depth. A study was also done on the effect of removal of tongue coating on VSC concentrations in mouth air from patients with periodontal involvement. VSC and the methyl mercaptan/hydrogen sulfide ratio were reduced to 49% and 35%, respectively, by removal of the tongue coating. The average amount of tongue coating removed from patients with periodontal disease was significantly higher than from controls (90.1 mg vs. 14.6 mg, p less than 0.01). Estimated production of VSC from tongue coating was 4 times higher than the control value, and the methyl mercaptan/hydrogen sulfide ratio was also markedly increased. However, a saliva putrefaction study suggested that saliva does not contribute to the elevated ratio of methyl mercaptan in mouth air. These results strongly suggest that, in addition to periodontal pockets, tongue coating has an important role in VSC production, in particular leading to an elevated concentration of methyl mercaptan, which is more pathogenic than hydrogen sulfide.
采用气相色谱法对口腔呼出气体中的挥发性硫化物（VSC）进行测定。牙周病患者口腔中VSC的含量以及甲硫醇/硫化氢的比例显著升高。这两个参数也随着出血指数和探诊深度的增加而升高。还对去除舌苔对牙周病患者口腔呼出气体中VSC浓度的影响进行了研究。通过去除舌苔，VSC和甲硫醇/硫化氢的比例分别降至49%和35%。牙周病患者去除的舌苔平均量显著高于对照组（90.1毫克对14.6毫克，p<0.01）。从舌苔中估计的VSC生成量比对照组高出4倍之多,并且甲硫醇/硫化氢的比例也显著升高。然而，一项唾液腐败研究表明，唾液并非导致口腔呼出气体中甲硫醇比例升高的原因。这些结果有力地表明，除牙周袋外，舌苔在VSC的产生中也起着重要作用，特别是导致甲硫醇浓度升高，而甲硫醇比硫化氢更具致病性。
