Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Baskent University, Ankara, Turkey.
J Clin Periodontol. 2014 Aug;41(8):814-9. doi: 10.1111/jcpe.12280. Epub 2014 Jul 7.
To analyse specific volatile sulphur compound(VSC) levels in a group of chronic renal failure (CRF) patients and determine the relationship between these VSC levels and organoleptic measurements, blood urea nitrogen (BUN) levels, dental and periodontal conditions, salivary flow rate, and tongue coating scores.
One examiner performed organoleptic and VSC measurements on fifty patients with CRF before and after haemodialysis (HD) and controls. DMFT and CPITN indexes, tongue coating scores, salivary flow rates were measured. Comparisons were performed using the Mann-Whitney U, Wilcoxon signed-ranks, and chi-square tests. Spearman correlation coefficient was used to analyse correlations.
Before HD, the mean dimethyl sulphide level was 1.04 ± 1.20 in the CRF patients and 0.51 ± 0.65 in controls, with a significant difference. The mean hydrogen sulphide, methyl mercaptan and dimethyl sulphide levels in CRF patients were 1.47 ± 3.04, 1.03 ± 1.85, and 1.04 ± 1.20, respectively, before HD; and 0.53 ± 1.65, 0.48 ± 1.27, and 0.56 ± 0.85, respectively, after HD; with the differences being significant. Methyl mercaptan levels increased with an increase in HD duration. Tongue coating and organoleptic measurements were significantly correlated with methyl mercaptan.
Dimethyl sulphide is the main VSC in extraoral blood-borne halitosis; but methyl mercaptan may also contribute to this type of halitosis. A decreased salivary flow rate and an increased pH of the biofilm matrix may be a significant parameter for VSC levels in CRF patients.
分析一组慢性肾衰竭（CRF）患者中特定挥发性硫化合物（VSC）的水平，并确定这些 VSC 水平与感官测量、血尿素氮（BUN）水平、口腔和牙周状况、唾液流量和舌苔评分之间的关系。
一名检查者在血液透析（HD）前后对 50 名 CRF 患者和对照组进行了感官和 VSC 测量。测量了 DMFT 和 CPITN 指数、舌苔评分和唾液流量。使用 Mann-Whitney U、Wilcoxon 符号秩和检验和卡方检验进行比较。使用 Spearman 相关系数分析相关性。
在 HD 之前，CRF 患者的二甲硫醚水平为 1.04 ± 1.20，对照组为 0.51 ± 0.65，差异有统计学意义。CRF 患者在 HD 前的氢硫化物、甲硫醇和二甲硫醚水平分别为 1.47 ± 3.04、1.03 ± 1.85 和 1.04 ± 1.20，HD 后分别为 0.53 ± 1.65、0.48 ± 1.27 和 0.56 ± 0.85，差异有统计学意义。甲硫醇水平随 HD 持续时间的增加而增加。舌苔和感官测量与甲硫醇显著相关。
二甲硫醚是外源性血源性口臭的主要 VSC，但甲硫醇也可能导致这种类型的口臭。唾液流量减少和生物膜基质 pH 值升高可能是 CRF 患者 VSC 水平的重要参数。
