评估人乳头瘤病毒在结膜肿瘤形成中的作用。
Evaluating the role of human papillomaviruses in conjunctival neoplasia.
作者信息
Tornesello M L, Duraturo M L, Waddell K M, Biryahwaho B, Downing R, Balinandi S, Lucas S B, Buonaguro L, Buonaguro F M
机构信息
Viral Oncology and AIDS Reference Centre, National Cancer Institute Fond. Pascale, Cappella Cangiani, I-80131 Naples, Italy.
出版信息
Br J Cancer. 2006 Feb 13;94(3):446-9. doi: 10.1038/sj.bjc.6602921.
Abstract
Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0-1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas.
摘要
通过广谱聚合酶链反应（PCR）在乌干达受试者的86份结膜肿瘤活检样本和63份结膜非肿瘤对照组织中检测黏膜、皮肤和疣状表皮发育不良（EV）相关的人乳头瘤病毒（HPV）。在25%（56份样本中的14份）的HIV阳性、10%（30份样本中的3份）的HIV阴性结膜肿瘤样本中检测到7种不同的EV相关HPV类型，包括一种假定的新HPV类型，以及两种黏膜HPV，而在对照受试者中很少检测到（0 - 1.6%）。在更晚期肿瘤阶段，高危HPV的缺失以及EV相关HPV类型的低检测频率（10%）使人对它们在结膜癌中的作用产生怀疑。
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