Tsuchiya Kazuyoshi, Nakanishi Naoyuki, Uetsuji Yasutomo, Nakamachi Eiji
Department of Precision Engineering, Tokai University, 1117 Kitakaname, Hiratsuka-city, Kanagawa, 259-1292, Japan.
Biomed Microdevices. 2005 Dec;7(4):347-53. doi: 10.1007/s10544-005-6077-8.
We focus on research to develop a compact human blood sampling device used for the Self Monitoring of Blood Glucose (SMBG). The SMBG comprises: (1) an indentation system using a shape memory alloy (SMA) actuator to force a microneedle through the skin; (2) a micro electrical pumping system to extract blood using a bimorph type piezoelectric microactuator; (3) a biosensor using an enzyme such as glucose oxidase (GOx) to detect and evaluate the amount of glucose in extracted blood. A titanium microneedle the same size as a female mosquito's labium (60 mum outer diameter, 25 mum inner diameter) was produced by the sputter deposition method. The mechanical design of the device was based upon the mosquito's blood sampling mechanism. The blood extraction system worked well. We measured the performance of the principal components: the indentation load for a microneedle of external diameter 100 mum was found to be 0.1 N. The pumping system has an extraction speed of about 2 mul/min for whole blood. This is similar to that achieved by the mosquito.
我们专注于开展研究，以开发一种用于自我血糖监测（SMBG）的紧凑型人体血液采样装置。自我血糖监测包括：（1）一个压痕系统，该系统使用形状记忆合金（SMA）致动器推动微针穿过皮肤；（2）一个微电泵系统，使用双压电晶片型压电微致动器抽取血液；（3）一种生物传感器，使用葡萄糖氧化酶（GOx）等酶来检测和评估抽取血液中的葡萄糖含量。通过溅射沉积法制造了一根与雌蚊下唇尺寸相同的钛微针（外径60μm，内径25μm）。该装置的机械设计基于蚊子的血液采样机制。血液抽取系统运行良好。我们测量了主要部件的性能：发现外径为100μm的微针的压痕负荷为0.1N。该泵系统对全血的抽取速度约为2μl/分钟。这与蚊子实现的速度相似。
