Issa M M, Shortliffe L M, Constantinou C E
Department of Urology, Stanford University School of Medicine, California.
J Urol. 1992 Aug;148(2 Pt 2):559-63; discussion 564-5. doi: 10.1016/s0022-5347(17)36653-3.
We investigated the effect of urinary tract infection on bladder and renal pelvic urodynamics in a rat model to examine the role of pressure during infection. Either an antibiotic solution (control group) or Escherichia coli with type 1 pili (infected group) was instilled into the bladder. After 2 to 6 days simultaneous continuous bladder and renal pelvic pressures were measured during urinary flows from less than 2 to greater than 20 ml./kg. per hour while the bladder filled and emptied. Bladder pressures from 50 to 100% of maximum capacity and maximum voiding pressures were significantly higher in the infected group than the control group (36.7 +/- 6.79 cm. water versus 25.5 +/- 5.21 cm. water, respectively, p less than 0.0001). Renal pelvic pressures were significantly higher in the infected group during bladder filling at all urinary flows examined and actually exceeded bladder pressure for the highest flows. We conclude that elevated renal pelvic pressures may contribute to renal changes observed during urinary tract infection.
我们在大鼠模型中研究了尿路感染对膀胱和肾盂尿动力学的影响，以检验感染期间压力的作用。将抗生素溶液（对照组）或带有1型菌毛的大肠杆菌（感染组）注入膀胱。2至6天后，在膀胱充盈和排空过程中，当尿流率从每小时小于2毫升/千克增加到大于20毫升/千克时，同时连续测量膀胱和肾盂压力。感染组膀胱压力在最大容量的50%至100%时以及最大排尿压力显著高于对照组（分别为36.7±6.79厘米水柱和25.5±5.21厘米水柱，p<0.0001）。在所有检测的尿流率下，感染组在膀胱充盈期间肾盂压力显著更高，并且在最高尿流率时实际上超过了膀胱压力。我们得出结论，肾盂压力升高可能导致尿路感染期间观察到的肾脏变化。
