Fichtner J, Boineau F G, Lewy J E, Shortliffe L M
Department of Urology, Stanford University School of Medicine, California, USA.
J Urol. 1998 Sep;160(3 Pt 1):887-91. doi: 10.1016/S0022-5347(01)62827-1.
We investigated whether oxybutynin could lower elevated renal pelvic pressures measured in a rat with an inbred unilateral congenital hydronephrosis. Simultaneous renal pelvic and bladder pressures were measured in 8 hydronephrotic rats and compared to those of 10 hydronephrotic rats treated with intravenous injection of 1.6 mg./kg. oxybutynin. Pressures were recorded at different urinary flow rates and during bladder filling and emptying. Hydronephrotic rats not given oxybutynin showed significantly higher renal pelvic pressures (e.g. p-bladder at 50% capacity = 8.9 +/- 3.1 cm. H2O, corresponding p-pelvis = 20.8 +/- 2.1 at very high urinary flow rates) than rats treated with oxybutynin. The latter had renal pelvic pressures similar to rats with normal non-hydronephrotic kidneys (e.g. p-bladder at 50% capacity = 10.1 +/- 3.5 cm. H2O, corresponding p-pelvis = 6.3 +/- 1.1 at very high urinary flow rates). Renal pelvic pressures were, moreover, lower than corresponding bladder pressures in contrast to the untreated hydronephrotic pelvic pressure that exceeded bladder pressure. This effect of oxybutynin in lowering elevated renal pelvic pressures in the obstructed kidney has not been described before and suggests a possible role for oxybutynin in this condition.
我们研究了奥昔布宁是否能降低近交系单侧先天性肾积水大鼠所测得的肾盂压力升高情况。在8只肾积水大鼠中同时测量肾盂和膀胱压力，并与10只静脉注射1.6毫克/千克奥昔布宁治疗的肾积水大鼠进行比较。在不同尿流率以及膀胱充盈和排空期间记录压力。未给予奥昔布宁的肾积水大鼠显示肾盂压力显著高于接受奥昔布宁治疗的大鼠（例如，膀胱容量为50%时压力 = 8.9±3.1厘米水柱，在非常高的尿流率下相应的肾盂压力 = 20.8±2.1）。后者的肾盂压力与具有正常非肾积水肾脏的大鼠相似（例如，膀胱容量为50%时压力 = 10.1±3.5厘米水柱，在非常高的尿流率下相应的肾盂压力 = 6.3±1.1）。此外，与未治疗的肾积水肾盂压力超过膀胱压力相反，肾盂压力低于相应的膀胱压力。奥昔布宁降低梗阻性肾脏中升高的肾盂压力的这种作用此前尚未见报道，提示奥昔布宁在这种情况下可能发挥作用。
