Pua Vernon Sc, Scolyer Richard A, Barnetson Ross Stc
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Australas J Dermatol. 2006 Feb;47(1):57-9. doi: 10.1111/j.1440-0960.2006.00225.x.
SUMMARY A 64-year-old woman presented with diffuse and numerous pigmented macules on her face and upper back. Histopathological examination of a skin punch biopsy of the rash showed a lichenoid dermatitis. The most likely offending drug was pravastatin. Cessation of pravastatin resulted in gradual fading of the pigmentation. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors have previously been reported to cause lichenoid drug eruptions.
摘要 一名64岁女性面部和上背部出现弥漫性大量色素沉着斑。对皮疹进行皮肤打孔活检的组织病理学检查显示为苔藓样皮炎。最可能的致病药物是普伐他汀。停用普伐他汀后色素沉着逐渐消退。此前已有报道称3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂可引起苔藓样药疹。
