Salna Michael P, Singer Hannah M, Dana Ali N
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Columbia University College of Physicians and Surgeons, New York City, NY, USA.
Case Rep Dermatol Med. 2017;2017:3418204. doi: 10.1155/2017/3418204. Epub 2017 Jul 31.
Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. Dermatologic events are often overlooked as arising from medications, particularly those which are taken chronically. Moreover, elderly patients are prone to pharmacologic interactions due to multiple medications. In this report, we describe a case of a statin-induced eczematous dermatitis with a psoriasis-like clinical presentation and review the skin manifestations that may arise from statin therapy.
An 82-year-old man with gout and hypercholesterolemia presented to dermatology clinic with new onset of pruritic, scaly erythematous plaques bilaterally on the extensor surfaces of his arms. He had never had similar lesions before. Despite various topical and systemic treatments over several months, the rash continued to evolve. The patient was then advised to discontinue his long-term statin, which led to gradual resolution of his symptoms. He was subsequently diagnosed with statin-induced eczematous dermatitis.
This case report describes an adverse cutaneous reaction to statins that is rarely reported in the literature. Medications, including longstanding therapies, should be suspected in cases of refractory dermatologic lesions.
他汀类药物是最常用于老年人的处方药之一，但并非没有副作用。皮肤事件常被忽视是由药物引起的，尤其是那些长期服用的药物。此外，老年患者由于多种药物联用容易发生药物相互作用。在本报告中，我们描述了一例具有银屑病样临床表现的他汀类药物诱发的湿疹性皮炎病例，并回顾了他汀类药物治疗可能出现的皮肤表现。
一名82岁患有痛风和高胆固醇血症的男性到皮肤科门诊就诊，其双臂伸侧出现新发的瘙痒性、鳞屑性红斑斑块。他以前从未有过类似病变。尽管数月来进行了各种局部和全身治疗，皮疹仍持续演变。随后建议患者停用长期服用的他汀类药物，症状逐渐缓解。他随后被诊断为他汀类药物诱发的湿疹性皮炎。
本病例报告描述了一种他汀类药物引起的不良皮肤反应，这在文献中很少报道。对于难治性皮肤病变，应怀疑包括长期治疗药物在内的药物。
