Russell Sarah, Oliaro Jane
Immune Signalling Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Immunol Cell Biol. 2006 Feb;84(1):107-13. doi: 10.1111/j.1440-1711.2005.01415.x.
Lymphocyte function is regulated by complex signalling responses to diverse extracellular inputs, and a cell will often receive multiple, conflicting signals at one time. The mechanisms by which a lymphocyte integrates these signals into a single cellular response are not well understood. An important factor in the integration of signals likely involves the regulation of access of signalling molecules to cell surface receptors and of receptor signals to morphological determinants within the cell. Recent studies have led to important advances in our understanding of both the mechanisms by which signals are compartmentalized in T cells and the physiological role played by such compartmentalization. We review progress in the field, with a particular focus on membrane microdomains or lipid rafts and on cell polarity.
淋巴细胞功能受对多种细胞外输入的复杂信号反应调节，而且细胞常常会同时接收多个相互冲突的信号。淋巴细胞将这些信号整合为单一细胞反应的机制尚未完全清楚。信号整合中的一个重要因素可能涉及信号分子与细胞表面受体结合以及受体信号与细胞内形态学决定因素结合的调控。最近的研究在我们对T细胞中信号分隔机制以及这种分隔所起的生理作用的理解方面取得了重要进展。我们综述该领域的进展，特别关注膜微区或脂筏以及细胞极性。
